| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | LAMA3; CMD1JJ; LAMA4*-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LAMA4抗体的3篇文献示例(注：以下内容为模拟生成，实际文献需通过数据库检索确认)：
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1. **文献名称**: *Laminin α4 (LAMA4) Expression in Tumor-Associated Blood Vessels Predicts Poor Prognosis in Breast Cancer*
**作者**: Smith JR, et al.
**摘要**: 本研究通过免疫组化(使用抗LAMA4抗体)分析了乳腺癌组织中LAMA4在血管内皮细胞的表达。发现高表达LAMA4与肿瘤转移和患者生存率降低相关，提示其作为预后标志物的潜力。
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2. **文献名称**: *Targeting LAMA4 with Neutralizing Antibodies Inhibits Angiogenesis in Colorectal Cancer Models*
**作者**: Tanaka M, et al.
**摘要**: 研究开发了特异性抗LAMA4单克隆抗体，并在结直肠癌小鼠模型中验证其抑制肿瘤血管生成的效果。抗体阻断LAMA4与整合素的相互作用，显著减少肿瘤生长和血管密度。
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3. **文献名称**: *LAMA4 Deficiency Alters Cardiac Fibrosis Pathways Revealed by Antibody-Based Proteomic Analysis*
**作者**: Chen L, et al.
**摘要**: 利用抗LAMA4抗体进行蛋白质组学分析，发现Lama4基因敲除小鼠心脏中纤维化相关蛋白表达异常，表明LAMA4通过调节细胞外基质重塑影响心肌病理性重构。
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如需具体文献，建议在PubMed或Web of Science检索关键词“LAMA4 antibody” + 研究领域(如cancer/angiogenesis)，并筛选近5年高被引论文。
The LAMA4 antibody is a tool used to detect laminin alpha-4 (LAMA4), a subunit of the heterotrimeric laminin family of extracellular matrix (ECM) proteins. Laminins are critical for basement membrane assembly and function, mediating cell adhesion, migration, and signaling. LAMA4. encoded by the *LAMA4* gene, forms laminin-411 (α4β1γ1) and laminin-421 (α4β2γ1), which are expressed in vascular, neural, and muscle tissues. These isoforms play roles in angiogenesis, tissue repair, and tumor microenvironment regulation.
LAMA4 antibodies are widely utilized in research to study ECM remodeling in developmental biology, cancer metastasis, and cardiovascular diseases. In cancer, LAMA4 exhibits dual roles: promoting tumor angiogenesis and invasiveness in some contexts, while suppressing metastasis in others, depending on isoform interactions and tissue specificity. Antibodies against LAMA4 enable detection via techniques like Western blot, immunohistochemistry, and immunofluorescence, aiding in localization and expression level analyses.
Studies using LAMA4 antibodies have highlighted its involvement in pathological conditions, including fibrosis, atherosclerosis, and muscular dystrophy. Recent interest focuses on its potential as a therapeutic target or biomarker for diseases linked to ECM dysregulation. However, functional complexity and isoform diversity necessitate careful validation of antibody specificity to ensure accurate experimental outcomes.
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