| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MLC2; CMH10 |
| WB Predicted band size | 19 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MYL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MYL2抗体的3篇代表性文献及其简要摘要：
1. **"MYL2 mutations in familial hypertrophic cardiomyopathy: functional characterization and genotype-phenotype correlations"**
- **作者**: Richard T. Wang et al.
- **摘要**: 本研究通过基因测序鉴定肥厚型心肌病(HCM)患者的MYL2突变，并利用特异性抗体进行Western blot分析，发现突变导致心肌肌球蛋白轻链2表达水平下降，与心脏收缩功能异常相关。
2. **"Cardiac myosin light chain 2 regulates ventricular chamber and cardiomyocyte size"**
- **作者**: Samantha B. Hinson et al.
- **摘要**: 通过构建MYL2敲除小鼠模型，结合免疫荧光和免疫组化技术(使用MYL2抗体)，证明MYL2缺失导致心室腔扩大和心肌细胞尺寸异常，提示其在心脏发育中的关键作用。
3. **"Antibody-based detection of MYL2 phosphorylation in ischemic heart disease"**
- **作者**: Michael J. Ackerman et al.
- **摘要**: 开发针对磷酸化MYL2的特异性抗体，发现心肌缺血患者样本中MYL2磷酸化水平显著升高，提示其可作为心肌损伤的生物标志物，并通过ELISA验证临床相关性。
注：以上文献信息为示例性内容，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。建议结合具体研究方向补充近5年内的最新研究。
The MYL2 antibody targets myosin regulatory light chain 2 (MYL2), a protein encoded by the MYL2 gene, which is part of the myosin complex essential for muscle contraction. MYL2. also known as ventricular/cardiac myosin light chain-2. is predominantly expressed in cardiac and skeletal muscle. It regulates the ATPase activity of myosin heavy chains, influencing the force and speed of muscle contraction. MYL2 plays a critical role in cardiac function, particularly in the ventricles, and mutations in this gene are linked to inherited cardiomyopathies, such as hypertrophic cardiomyopathy (HCM), characterized by abnormal ventricular thickening.
Antibodies against MYL2 are widely used in research to study its expression, localization, and interaction within muscle tissues. They are vital tools in immunohistochemistry, Western blotting, and immunofluorescence to investigate MYL2's role in normal physiology and disease mechanisms. For example, MYL2 antibodies help identify protein levels in heart failure models or assess MYL2 phosphorylation status, which modulates contractility. Additionally, they aid in diagnosing MYL2-related genetic disorders by detecting aberrant protein expression in patient samples. Commercial MYL2 antibodies are typically validated for specificity across species, enabling cross-disciplinary studies in cardiovascular research and therapeutic development targeting MYL2 dysregulation.
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