| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | BG; BG1; BGM; LPD; GR-LACS |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ACSBG1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ACSBG1抗体的3篇模拟参考文献(基于常见研究方向假设，仅供参考)：
1. **《ACSBG1在胶质母细胞瘤中的脂代谢调控作用》**
- 作者：Smith A, et al.
- 摘要：研究利用ACSBG1特异性抗体，通过免疫组化和Western blot技术，揭示其在胶质母细胞瘤中通过合成长链脂肪酸辅酶A促进肿瘤细胞增殖的机制。
2. **《ACSBG1抗体在小鼠睾丸组织中的定位分析》**
- 作者：Zhang L, et al.
- 摘要：通过开发多克隆ACSBG1抗体，首次在睾丸支持细胞中检测到该蛋白的高表达，提示其参与精子形成过程中的脂质代谢调控。
3. **《ACSBG1基因敲除模型中抗体验证与表型研究》**
- 作者：Wang X, et al.
- 摘要：利用ACSBG1抗体验证基因敲除小鼠模型，发现其缺失导致脑部脂质沉积异常，证实该蛋白在神经系统脂质稳态中的关键作用。
**注**：以上文献为模拟示例，实际引用需查询具体数据库(如PubMed)获取真实研究。若需进一步协助文献检索，请提供更多背景信息。
The ACSBG1 (acyl-CoA synthetase bubblegum family member 1) antibody is a tool used to study the function and expression of the ACSBG1 enzyme, which plays a critical role in fatty acid metabolism. ACSBG1 is part of the acyl-CoA synthetase family, responsible for activating long-chain fatty acids by catalyzing their conversion into acyl-CoA derivatives. This step is essential for fatty acid transport into mitochondria for β-oxidation or integration into complex lipids. Unlike other family members, ACSBG1 is primarily expressed in the brain, testis, and adrenal glands, suggesting specialized roles in lipid metabolism within these tissues. Research highlights its importance in neurological health, as mutations in the ACSBG1 gene are linked to neurodegenerative disorders, including hereditary spastic paraplegia and adrenoleukodystrophy-like phenotypes.
The ACSBG1 antibody enables detection and localization of the protein in cells or tissues, aiding investigations into its physiological and pathological roles. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using this antibody have revealed ACSBG1's involvement in maintaining lipid homeostasis, particularly in myelination processes and neuronal function. Dysregulation of ACSBG1 has been associated with lipid accumulation, oxidative stress, and impaired energy production, emphasizing its relevance in metabolic and neurodegenerative diseases. By targeting specific epitopes of ACSBG1. the antibody helps researchers explore therapeutic strategies for related disorders, bridging molecular insights with clinical applications.
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