| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | STAM1; STAM-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human STAM |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于STAM抗体的3篇参考文献，涵盖其功能、相互作用及疾病关联研究：
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1. **文献名称**: *"Molecular Cloning and Characterization of a Novel Signal-transducing Adaptor Molecule, STAM"*
**作者**: Takeshita T, et al.
**摘要**: 该研究首次克隆并鉴定了STAM基因，发现其作为信号转导适配分子，通过SH3结构域与JAK激酶相互作用，参与细胞因子(如IL-2)下游的信号传导，调控细胞增殖与分化。
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2. **文献名称**: *"STAM and Hrs Form a Complex to Regulate EGFR Endosomal Sorting"*
**作者**: Kobayashi H, Tanaka N.
**摘要**: 研究揭示了STAM与Hrs蛋白形成复合体，通过调控表皮生长因子受体(EGFR)的内吞和溶酶体降解，影响受体下游信号通路的持续性与终止，为生长因子信号动态平衡提供机制解释。
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3. **文献名称**: *"STAM Adaptor Proteins in Immune Regulation and Cancer Progression"*
**作者**: Mizuno E, et al.
**摘要**: 本文综述了STAM家族蛋白(STAM1/STAM2)在免疫细胞活化及肿瘤微环境中的作用，指出其在调控炎症因子信号(如IFN-γ)和促进肿瘤转移中的双重功能，提示其作为潜在治疗靶点的可能性。
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**注**：以上文献为模拟示例，实际引用需根据具体研究需求检索PubMed或Web of Science等数据库获取原文信息。
STAM (Signal Transducing Adaptor Molecule) antibodies are tools used to study the STAM family of adaptor proteins, which play critical roles in intracellular signal transduction and membrane trafficking. Discovered in the mid-1990s, STAM proteins (STAM1 and STAM2) are evolutionarily conserved and interact with components of the endosomal sorting complex required for transport (ESCRT) machinery. They function as adaptors, linking receptor tyrosine kinases, cytokine receptors, and other signaling molecules to downstream pathways regulating cell growth, differentiation, and endocytic sorting.
Structurally, STAM proteins contain VHS (Vps27. Hrs, STAM), SH3 (Src homology 3), and ITAM (immunoreceptor tyrosine-based activation motif) domains. These domains enable interactions with ubiquitinated cargo (via VHS), signaling partners (via SH3), and tyrosine kinases (via phosphorylated ITAM). STAM antibodies specifically target these domains or post-translational modifications (e.g., tyrosine phosphorylation) to investigate their roles in processes like receptor downregulation, multivesicular body formation, and viral budding.
Research utilizing STAM antibodies has elucidated their involvement in diseases, including cancer (via dysregulated growth signaling) and immunodeficiency disorders. They remain essential for studying ESCRT-mediated membrane trafficking and cytokine signaling pathways in both physiological and pathological contexts.
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