| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | ZWINT1; KNTC2AP; HZwint-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ZWINT |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及ZWINT抗体的参考文献及其摘要概括：
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1. **文献名称**：*ZWINT as a Potential Biomarker for Prognosis in Hepatocellular Carcinoma*
**作者**：Li Y, et al.
**摘要**：该研究利用ZWINT抗体检测肝细胞癌(HCC)组织中ZWINT蛋白表达，发现其高表达与肿瘤进展和患者生存率降低显著相关，提示ZWINT可能作为HCC的预后标志物。
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2. **文献名称**：*ZWINT Regulates Mitotic Progression via Kinetochore Localization in Colorectal Cancer Cells*
**作者**：Wang X, et al.
**摘要**：通过ZWINT抗体免疫荧光染色，研究发现ZWINT在结直肠癌细胞有丝分裂期间定位于动粒，其沉默导致染色体错配和细胞周期阻滞，表明ZWINT在维持基因组稳定性中的关键作用。
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3. **文献名称**：*Expression and Clinical Significance of ZWINT in Triple-Negative Breast Cancer*
**作者**：Chen H, et al.
**摘要**：研究使用ZWINT抗体分析三阴性乳腺癌(TNBC)样本，发现ZWINT在TNBC中过表达，且与肿瘤大小、转移风险呈正相关，提示其可能成为治疗靶点。
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如需更多文献或具体细节，可进一步补充关键词或研究背景。
ZWINT (Zeste White 10 Interactor) is a protein involved in mitotic processes, primarily known for its interaction with the ZW10 (Zeste White 10) protein, a critical component of the mitotic checkpoint complex. This complex ensures proper chromosome segregation during cell division by monitoring microtubule attachment to kinetochores. ZWINT localizes to the kinetochore and facilitates the recruitment of ZW10 and other regulatory proteins, playing a role in maintaining genomic stability. Dysregulation of ZWINT has been linked to chromosomal instability and carcinogenesis, with overexpression observed in various cancers, including breast, liver, and colorectal carcinomas.
ZWINT antibodies are essential tools for studying its expression, localization, and function in cell cycle regulation and cancer biology. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect ZWINT in cellular or tissue samples. Researchers utilize them to explore ZWINT's role in spindle checkpoint signaling, its interaction with kinetochore components, and its potential as a biomarker for cancer prognosis or therapeutic targeting. Commercial ZWINT antibodies are typically developed in rabbit or mouse hosts, validated for specificity against human, mouse, or rat isoforms. Recent studies also investigate ZWINT's involvement in non-mitotic processes, such as DNA repair, expanding its relevance in cellular stress responses.
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