Rabbit Polyclonal PIP5K1B Antibody

The PIP5K1B antibody is a crucial tool for studying the phosphatidylinositol-4-phosphate 5-kinase type 1 beta (PIP5K1B), an enzyme encoded by the *PIP5K1B* gene. PIP5K1B belongs to the phosphatidylinositol-4-phosphate 5-kinase family, which catalyzes the synthesis of phosphatidylinositol-4.5-bisphosphate (PIP2), a key lipid secondary messenger regulating cellular processes like membrane trafficking, cytoskeletal organization, and signal transduction. PIP5K1B localizes to the plasma membrane and intracellular vesicles, playing roles in receptor signaling, exocytosis, and cell migration. Dysregulation of PIP5K1B is implicated in cancer, neurological disorders, and immune dysfunctions. For instance, elevated PIP5K1B expression correlates with tumor progression in certain cancers, while mutations are linked to neurodevelopmental conditions. The PIP5K1B antibody enables detection and quantification of the protein in various applications, including Western blotting, immunohistochemistry, and immunofluorescence, aiding research into its mechanistic roles and therapeutic targeting. Validated antibodies help assess PIP5K1B expression patterns, post-translational modifications, and interactions in disease models. Recent studies also explore its potential as a biomarker or drug target, particularly in oncology. Researchers rely on high-specificity PIP5K1B antibodies to dissect its contributions to lipid-mediated signaling pathways and disease pathogenesis.