| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | PA; AMY2; AMY2B |
| WB Predicted band size | 58 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human AMY2A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3条与AMY2A抗体相关的假设性参考文献示例(文献内容为虚构，仅作格式参考)：
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1. **文献名称**: "Development of a Monoclonal Antibody for Human Pancreatic α-Amylase (AMY2A) and Its Application in Tissue Localization"
**作者**: Smith J, et al.
**摘要**: 本研究报道了一种新型抗人AMY2A单克隆抗体的开发，通过免疫印迹和免疫组化验证其特异性。该抗体成功用于胰腺组织切片中AMY2A蛋白的定位分析，证实其在慢性胰腺炎患者中的表达下调。
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2. **文献名称**: "AMY2A Gene Variants and Protein Expression in Type 2 Diabetes Mellitus"
**作者**: Tanaka K, et al.
**摘要**: 通过ELISA和Western blot分析AMY2A抗体检测的血清及胰腺样本，发现携带AMY2A特定基因变异的2型糖尿病患者中，其蛋白活性显著降低，提示AMY2A功能异常可能与糖代谢紊乱相关。
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3. **文献名称**: "Comparative Analysis of AMY2A Antibody Performance in Commercial Assay Kits"
**作者**: Müller R, et al.
**摘要**: 评估了4种市售AMY2A抗体的灵敏度和交叉反应性，发现抗体Clone#3H9在区分AMY2A与唾液淀粉酶(AMY1A)方面表现最优，为临床诊断提供了可靠的检测工具。
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注：以上文献为示例性质，实际研究中请通过PubMed或Web of Science等数据库检索真实文献。
The AMY2A antibody targets the α-amylase 2A (AMY2A) enzyme, a pancreatic isoform of human α-amylase encoded by the *AMY2A* gene. AMY2A is primarily expressed in the pancreas and secreted into the digestive tract, where it catalyzes the hydrolysis of starch into sugars. This enzyme plays a critical role in carbohydrate metabolism and nutrient absorption. AMY2A antibodies are widely used in research to study pancreatic exocrine function, enzyme secretion mechanisms, and pathologies like pancreatitis, diabetes, or pancreatic cancer.
As a monoclonal or polyclonal antibody, AMY2A-specific reagents enable the detection and quantification of the enzyme in tissues (via immunohistochemistry) or biological fluids (via ELISA/Western blot). Elevated AMY2A levels in serum often indicate pancreatic injury, making it a diagnostic marker for acute pancreatitis. Conversely, reduced expression may link to pancreatic insufficiency or chronic conditions. Recent studies also explore its role in metabolic disorders and cancer progression, as aberrant amylase activity may influence tumor microenvironments.
Commercial AMY2A antibodies are typically validated for specificity against homologous isoforms (e.g., AMY1A or AMY2B) to avoid cross-reactivity. Ongoing research aims to refine its clinical utility, including therapeutic targeting and biomarker development.
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