| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human BIN3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是假设性的关于BIN3抗体的参考文献示例(实际文献需通过学术数据库验证)：
1. **"BIN3 regulates endosomal trafficking and cell migration through its interaction with cytoskeletal proteins"**
- **作者**: Johnson, A. et al. (2016)
- **摘要**: 研究利用BIN3特异性抗体，通过免疫共沉淀和免疫荧光技术，揭示BIN3通过与肌动蛋白结合蛋白相互作用调控内体运输和细胞迁移的机制。
2. **"Development and characterization of a monoclonal antibody targeting BIN3 for cancer biomarker studies"**
- **作者**: Lee, S. & Kim, H. (2019)
- **摘要**: 报道了一种新型BIN3单克隆抗体的开发，验证了其在Western blot和免疫组化中的特异性，并发现BIN3在乳腺癌组织中的表达与预后相关。
3. **"BIN3 deficiency disrupts synaptic vesicle recycling in neuronal cells: Evidence from antibody-based imaging"**
- **作者**: Martinez, R. et al. (2020)
- **摘要**: 使用BIN3抗体进行超分辨率显微镜观察，发现BIN3缺失导致神经元突触小泡循环异常，提示其在神经退行性疾病中的潜在作用。
4. **"The role of BIN3 in Hippo signaling pathway: Insights from knockout models and antibody-mediated protein localization"**
- **作者**: Wang, Y. et al. (2021)
- **摘要**: 通过BIN3抗体染色和基因敲除实验，证明BIN3通过调控Hippo通路核心成分的亚细胞定位影响器官大小和肿瘤发生。
**注意**：以上为示例文献，实际研究中建议通过PubMed、Google Scholar等平台以关键词“BIN3 antibody”或“BIN3 protein function”检索最新文献。
The BIN3 (Bridging Integrator 3) antibody is a tool used to study the BIN3 protein, a member of the BAR (Bin/Amphiphysin/Rvs) domain-containing protein family. BIN3 is implicated in membrane dynamics, cytoskeletal organization, and intracellular trafficking. It interacts with phospholipids and other proteins to regulate membrane curvature, vesicle formation, and receptor endocytosis, influencing processes like cell migration, polarity, and signaling. BIN3 is also linked to pathways such as Hippo, which controls organ size and tumor suppression, and may interact with actin-modulating proteins.
Research associates BIN3 with cancer progression, neurological disorders, and immune regulation, though its exact mechanisms remain under investigation. The BIN3 antibody enables detection and localization of BIN3 in cells or tissues via techniques like Western blotting, immunofluorescence, or immunohistochemistry. It helps explore BIN3’s expression patterns, post-translational modifications, and interactions in normal or diseased states. Commercial BIN3 antibodies are typically raised against specific epitopes (e.g., human BIN3 N-terminal regions) and validated for specificity. Studying BIN3 may reveal insights into membrane-cytoskeleton interplay and its role in pathologies, potentially aiding therapeutic target discovery.
×
