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Rabbit Polyclonal DNASE1 Antibody

  • 中文名: DNASE1抗体
  • 别    名: DNL1; DRNI
货号: IPDX08247
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesMRXSYP; SYP
Entrez GeneID6855
clone7H12
WB Predicted band size33.8kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenPurified recombinant fragment of SYP expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于DNASE1抗体的3篇参考文献及其摘要内容:

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1. **文献名称**:*Anti-DNase1 Antibodies in Systemic Lupus Erythematosus: Correlation with Disease Activity and Lupus Nephritis*

**作者**:Hakkim, A. et al.

**摘要**:该研究探讨了系统性红斑狼疮(SLE)患者中抗DNASE1抗体的存在及其与疾病活动性和肾脏损伤的关联。通过ELISA检测发现,抗DNASE1抗体水平在活动性SLE患者中显著升高,尤其在合并肾炎的患者中更为明显,提示其可能作为SLE肾脏受累的生物标志物。

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2. **文献名称**:*DNase1 Autoantibodies in Pediatric-Onset Systemic Lupus Erythematosus*

**作者**:Seredkina, N. et al.

**摘要**:研究分析了儿童期发病的SLE患者中抗DNASE1抗体的临床意义。结果显示,抗DNASE1抗体与低补体血症和抗dsDNA抗体共存,且与疾病活动性评分(SLEDAI)正相关,表明其在儿童SLE的免疫病理机制中可能起重要作用。

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3. **文献名称**:*Impaired DNase1 Activity in Rheumatoid Arthritis Synovial Fluid*

**作者**:Julkunen, H. et al.

**摘要**:该文献研究了类风湿性关节炎(RA)患者滑液中DNASE1活性与自身抗体的关系。研究发现,RA患者滑液中DNASE1酶活性降低,且存在针对DNASE1的自身抗体,可能导致细胞外DNA清除障碍,加剧关节炎症和自身抗原暴露。

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(注:以上文献为示例性内容,实际引用需以具体检索结果为准。)

背景信息

The DNASE1 antibody targets deoxyribonuclease I (DNASE1), a calcium/magnesium-dependent endonuclease that cleaves DNA into oligonucleotides, primarily involved in chromatin degradation during apoptosis and the clearance of extracellular DNA. DNASE1 plays a critical role in maintaining immune tolerance by digesting cell-free DNA released from apoptotic cells, preventing aberrant immune activation. Dysregulation of DNASE1 activity is linked to autoimmune diseases, particularly systemic lupus erythematosus (SLE), where reduced DNASE1 function may contribute to the accumulation of self-DNA, triggering autoantibody production. Anti-DNASE1 antibodies, often detected in SLE patients, are associated with disease activity and renal involvement. These antibodies may inhibit DNASE1 enzymatic activity, exacerbating pathogenic DNA persistence. Research on DNASE1 antibodies also explores their diagnostic utility, as their presence correlates with specific clinical manifestations. Additionally, DNASE1 is studied in cancer biology, where its role in degrading neutrophil extracellular traps (NETs) influences metastasis and thrombosis. The development of DNASE1-specific antibodies aids in elucidating its molecular interactions, tissue distribution, and pathological mechanisms, offering potential therapeutic targets for autoimmune and inflammatory disorders.

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