| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK |
| WB Predicted band size | 116 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PTK2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PTK2B抗体的3篇示例文献(内容为模拟概括，仅供参考)：
1. **文献名称**：PTK2B regulates tau phosphorylation and Aβ-mediated synaptic toxicity
**作者**：Sharma, P. et al.
**摘要**：本研究利用特异性PTK2B抗体探究了PTK2B在阿尔茨海默病中的作用，发现其通过激活下游激酶促进tau蛋白异常磷酸化，并加剧β淀粉样蛋白(Aβ)诱导的突触功能障碍。
2. **文献名称**：A novel monoclonal antibody targeting PTK2B inhibits cancer cell invasion
**作者**：Chen, L. & Zhang, W.
**摘要**：开发了一种高特异性抗PTK2B单克隆抗体，证实其可通过阻断PTK2B/FAK信号通路抑制乳腺癌细胞的迁移和侵袭能力，为靶向治疗提供潜在工具。
3. **文献名称**：PTK2B expression in hippocampal neurons: An immunohistochemical study
**作者**：Girault, J.A. et al.
**摘要**：通过免疫组化结合PTK2B抗体，揭示了PTK2B在海马神经元中的亚细胞定位，及其在突触可塑性和学习记忆相关信号通路中的动态表达变化。
建议通过PubMed或Google Scholar搜索关键词“PTK2B antibody”或“PYK2 antibody”获取最新文献，并注意选择高影响力期刊的研究(如Nature、Cell子刊或神经科学/肿瘤学领域期刊)。
PTK2B (Protein Tyrosine Kinase 2 Beta), also known as PYK2 or FAK2. is a cytoplasmic non-receptor tyrosine kinase belonging to the focal adhesion kinase (FAK) family. It plays critical roles in cell signaling, particularly in calcium-regulated pathways, cell adhesion, migration, and proliferation. PTK2B is activated by intracellular calcium influx, inflammatory cytokines, and stress signals, interacting with integrins, Src-family kinases, and cytoskeletal proteins to regulate cellular responses. Its dysregulation has been implicated in neurological disorders, including Alzheimer’s disease (AD), where PTK2B interacts with tau protein and amyloid-beta plaques, contributing to synaptic dysfunction and neurodegeneration. Genome-wide association studies also link PTK2B genetic variants to AD susceptibility. In cancer, PTK2B overexpression correlates with tumor metastasis, drug resistance, and poor prognosis by promoting survival signaling in malignant cells.
PTK2B antibodies are essential tools for detecting and studying this kinase’s expression, activation (e.g., phosphorylation at Tyr402), and localization in tissues or cell lines. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore PTK2B’s role in disease mechanisms or therapeutic targeting. Researchers employ these antibodies to validate PTK2B as a potential biomarker or to assess the efficacy of kinase inhibitors in preclinical models. Given its dual role in neurodegeneration and oncology, PTK2B remains a focal point for developing targeted therapies, underscoring the importance of high-specificity antibodies in both basic and translational research.
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