| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SLIM; MYSTIQUE |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human PDLIM2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与PDLIM2抗体相关的文献示例(信息基于公开研究归纳，非真实文献，仅供参考)：
1. **文献名称**：PDLIM2 suppresses tumor metastasis via actin cytoskeleton remodeling
**作者**：Smith A, et al.
**摘要**：研究通过Western blot和免疫荧光技术，利用PDLIM2特异性抗体证明其在乳腺癌中通过调控细胞骨架蛋白抑制肿瘤细胞迁移，抗体特异性验证显示与PDLIM1无交叉反应。
2. **文献名称**：PDLIM2 modulates inflammatory signaling in macrophages
**作者**：Chen L, et al.
**摘要**：利用PDLIM2敲除小鼠模型，结合免疫组化(IHC)和流式细胞术，发现PDLIM2抗体标记的蛋白通过抑制NF-κB通路减轻炎症反应，抗体特异性经siRNA敲低实验验证。
3. **文献名称**：PDLIM2 as a biomarker in colorectal cancer progression
**作者**：Wang Y, et al.
**摘要**：通过免疫组织化学分析临床样本，发现PDLIM2抗体检测的高表达与结直肠癌患者生存率正相关，研究强调其作为预后标志物的潜力，抗体验证采用重组蛋白阻断对照。
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**备注**：实际文献需通过PubMed/Google Scholar以"PDLIM2 antibody"为关键词检索，建议结合实验目的(如癌症、免疫)筛选近年高引论文，并注意抗体货号及验证数据。
The PDLIM2 (PDZ and LIM domain protein 2) antibody is a tool used to detect the PDLIM2 protein, a multifunctional adaptor protein encoded by the *PDLIM2* gene in humans. PDLIM2 contains a PDZ domain, which mediates protein-protein interactions, and a LIM domain, involved in cytoskeletal organization and signal transduction. It plays roles in cell adhesion, migration, and transcriptional regulation by targeting transcription factors (e.g., NF-κB) to proteasomal degradation or specific subcellular compartments, thereby modulating inflammatory responses and oncogenic pathways.
PDLIM2 is implicated in various diseases, including cancer, where it exhibits dual roles as a tumor suppressor or promoter depending on context. It regulates metastasis in breast and prostate cancers but may promote survival in T-cell malignancies. In immunology, PDLIM2 modulates macrophage polarization and T-cell activation, linking it to autoimmune diseases and chronic inflammation. Its role in viral infections, such as HIV, has also been explored due to its interaction with viral proteins.
PDLIM2 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein expression, localization, and interactions. Commercial antibodies are typically raised in rabbits or mice, with specificity validated across research models. Understanding PDLIM2's complex functions through these antibodies aids in unraveling its therapeutic potential in cancer, immune disorders, and infectious diseases.
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