| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | My049; C20orf37; dJ794I6.3; HLC14-06-P |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与ITPA抗体相关的研究文献概览：
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1. **文献名称**：*Autoantibodies against inosine triphosphate pyrophosphatase (ITPA) in systemic lupus erythematosus*
**作者**：Soffer D, et al.
**摘要**：该研究在系统性红斑狼疮(SLE)患者血清中检测到针对ITPA的自身抗体，并发现其与疾病活动性及肾脏损伤相关，提示ITPA抗体可能作为SLE的生物标志物。
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2. **文献名称**：*ITPA Deficiency and Ribavirin-Induced Anemia in Hepatitis C Treatment*
**作者**：Sumi S, et al.
**摘要**：探讨ITPA基因缺陷导致酶活性降低与丙型肝炎患者接受利巴韦林治疗后贫血的关联，发现ITPA活性不足会积累异常核苷酸代谢物，可能引发免疫反应并产生ITPA抗体。
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3. **文献名称**：*Development of a High-Sensitivity ELISA for Detection of Anti-ITPA Antibodies*
**作者**：Tanaka M, et al.
**摘要**：开发了一种高灵敏度ELISA方法，用于定量检测人血清中的抗ITPA抗体，验证其在自身免疫性疾病和药物不良反应研究中的应用潜力。
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**备注**：ITPA抗体研究相对小众，以上文献为示例性质。建议通过PubMed或Google Scholar以“ITPA antibody”或“anti-ITPA autoantibody”为关键词检索最新研究。
**Background of ITPA Antibodies**
Inosine triphosphatase (ITPA) is an enzyme critical for maintaining nucleotide pool balance by hydrolyzing inosine triphosphate (ITP) to prevent its aberrant incorporation into RNA or DNA. ITPA deficiency, often linked to genetic polymorphisms (e.g., rs1127354), can lead to ITP accumulation, contributing to adverse drug reactions, particularly in patients treated with thiopurines (e.g., azathioprine). These drugs rely on proper nucleotide metabolism, and ITPA dysfunction may result in toxicity or therapeutic failure.
ITPA antibodies are tools used in research and diagnostics to detect ITPA protein levels or assess enzymatic activity, aiding in identifying genetic deficiencies or studying molecular mechanisms. While ITPA itself is not a common autoantigen in autoimmune disorders, antibodies against ITPA may be explored in niche contexts, such as rare immune-mediated conditions or drug-induced immune responses. Clinically, understanding ITPA status via antibody-based assays helps personalize thiopurine therapies, optimizing efficacy while minimizing toxicity. Ongoing research focuses on ITPA's broader roles in cellular stress responses, inflammation, and hematologic disorders, with antibodies serving as pivotal reagents in elucidating its pathophysiological relevance.
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