| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | PIR1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于DUSP11抗体的3篇文献示例(内容基于公开研究整理，非真实文献，仅供参考)：
---
1. **标题**：DUSP11 Regulates Viral RNA Splicing through Dephosphorylation of SR Proteins
**作者**：Smith A, et al.
**摘要**：研究利用DUSP11特异性抗体，通过免疫沉淀和质谱分析，发现DUSP11通过去磷酸化SR蛋白调控RNA剪接，影响宿主抗病毒反应。
2. **标题**：Characterization of DUSP11 Antibody for Detecting RNA Phosphatase Activity in Human Cells
**作者**：Lee J, et al.
**摘要**：开发并验证了一种高特异性DUSP11抗体，通过Western blot和免疫荧光证实其在检测DUSP11介导的RNA 5'-三磷酸去磷酸化中的关键作用。
3. **标题**：DUSP11 Deficiency Alters snoRNA Processing via Its Interaction with Box C/D Complexes
**作者**：Garcia R, et al.
**摘要**：使用DUSP11抗体进行染色质共沉淀实验，揭示DUSP11通过与Box C/D复合物结合调控snoRNA加工，影响核糖体RNA成熟。
---
如需真实文献，建议通过PubMed或Google Scholar以“DUSP11 antibody”或“DUSP11 phosphatase”为关键词检索近年论文。
**Background of DUSP11 Antibody**
DUSP11 (Dual Specificity Phosphatase 11), also known as RNA/RNP complex-1-interacting phosphatase (RIP1), is a member of the dual-specificity phosphatase family. Unlike many DUSPs that dephosphorylate mitogen-activated protein kinases (MAPKs), DUSP11 primarily regulates RNA metabolism and processing by targeting phospho-residues in RNA molecules or RNA-associated proteins. It plays a role in modulating RNA splicing, stability, and viral RNA replication by interacting with RNA-protein complexes.
Antibodies against DUSP11 are essential tools for studying its expression, localization, and function in cellular pathways. They enable detection of endogenous DUSP11 in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. Research using DUSP11 antibodies has highlighted its involvement in stress responses, cell cycle regulation, and antiviral defense mechanisms. For instance, DUSP11 has been implicated in regulating the replication of certain RNA viruses by dephosphorylating viral RNA, thereby influencing host-pathogen interactions.
Dysregulation of DUSP11 has been linked to cancer and neurological disorders, underscoring its potential as a therapeutic target. Validated DUSP11 antibodies are critical for exploring its molecular mechanisms, substrate specificity, and interactions with RNA-binding proteins. These antibodies are often developed in hosts like rabbits or mice, with specificity confirmed through knockout/knockdown controls to ensure reliability in experimental models.
×
