| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OSCAR |
| Uniprot No | Q8IYS5-7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 19-286aa |
| 氨基酸序列 | MGSSHHHHHH SSGLVPRGSH MGSDITPSVA IIVPPASYHP KPWLGAQPAT VVTPGVNVTL RCRAPQPAWR FGLFKPGEIA PLLFRDVSSE LAEFFLEEVT PAQGGIYRCC YRRPDWGPGV WSQPSDVLEL LVTEELPRPS LVALPGPVVG PGANVSLRCA GRLRNMSFVL YREGVAAPLQ YRHSAQPWAD FTLLGARAPG TYSCYYHTPS APYVLSQRSE VLVISWEGEG PEARPASSAP GMQAPGPPPS DPGAQAPSLS SFRPRGLVLQ PLLPQTQDSW DPAPPPSDPG V |
| 预测分子量 | 31 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
1. **《OSCAR is a collagen receptor on osteoclasts critical for bone resorption》**
作者：Kim, N. et al.
摘要：该研究揭示了OSCAR作为破骨细胞表面胶原受体在骨吸收中的关键作用，重组OSCAR蛋白被用于验证其与胶原结合并激活下游信号通路，调控破骨细胞分化与功能。
2. **《Recombinant OSCAR modulates osteoclastogenesis and inflammation in arthritis models》**
作者：Hermann, M. et al.
摘要：通过表达重组OSCAR蛋白，研究发现其在类风湿性关节炎模型中能抑制破骨细胞过度活化，并减轻关节炎症，提示其作为潜在治疗靶点的可能性。
3. **《Structural insights into OSCAR recognition by monoclonal antibodies》**
作者：Zhang, Y. et al.
摘要：利用重组OSCAR蛋白进行晶体结构分析，揭示了其与特定单克隆抗体的结合表位，为开发靶向OSCAR的免疫疗法提供结构基础。
4. **《OSCAR acts as a decoy receptor in dendritic cells to regulate T cell responses》**
作者：Barrow, A.D. et al.
摘要：研究通过重组OSCAR蛋白实验证明，其在树突状细胞中通过竞争性结合配体调控T细胞免疫应答，参与维持免疫稳态及炎症疾病进程。
OSCAR (Osteoclast Associated Receptor) is a cell surface protein initially identified for its role in osteoclast differentiation and bone remodeling. Belonging to the immunoglobulin superfamily, OSCAR is expressed primarily on osteoclasts, immune cells like dendritic cells, and certain lymphocytes. It functions as a co-stimulatory receptor, interacting with ligands such as collagen-related peptides or specific Fc receptor gamma (FcRγ) chains to activate signaling pathways like NFAT and NF-κB, which regulate osteoclastogenesis and immune responses.
In bone biology, OSCAR is critical for osteoclast maturation and resorption activity, making it a key player in diseases like osteoporosis and rheumatoid arthritis. Its dual role in immune regulation—modulating cytokine production and antigen presentation—links bone metabolism with inflammatory processes. Dysregulated OSCAR expression is associated with autoimmune disorders and pathological bone loss.
Recombinant OSCAR proteins, produced via mammalian or bacterial expression systems, are valuable tools for studying these mechanisms. They enable researchers to explore receptor-ligand interactions, screen therapeutic agents, or develop biologics targeting OSCAR-related pathways. For instance, blocking OSCAR signaling with recombinant variants or antibodies could potentially inhibit excessive osteoclast activity in bone diseases or dampen inflammation in autoimmune conditions. Recent studies also suggest OSCAR's involvement in tumor microenvironment regulation, expanding its therapeutic relevance. As research progresses, OSCAR recombinant proteins may pave the way for novel treatments bridging immunology and skeletal health.
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