关键信息
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基因名
PDCD4
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简介
PDCD4 inhibits translation initiation by disrupting the EIF4A1-EIF4G interaction and inhibiting EIF4A helicase activity. It regulates JUN kinase activation and downregulates MAP4K1, inhibiting invasion and tumorigenesis. PDCD4 Protein, Human (His) is the recombinant human-derived PDCD4 protein, expressed by E. coli , with C-6*His labeled tag.
- 应用
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别名
Programmed Cell Death Protein 4; Neoplastic Transformation Inhibitor Protein; Nuclear Antigen H731-Like; Protein 197/15a; PDCD4; H731
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种属
Human
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q53EL6
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表达区间
K212-P357
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蛋白长度
Partial
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分子量
17.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
TWSG1 (Twisted Gastrulation Protein 1) is a secreted extracellular matrix protein that plays a vital role in embryonic development and tissue patterning by modulating the activity of bone morphogenetic proteins (BMPs). Its significance in developmental biology stems from its ability to influence cellular processes such as proliferation, differentiation, and apoptosis, thereby impacting organogenesis and morphogenesis. Dysregulation of TWSG1 has been linked to various developmental disorders and diseases, including certain forms of cancer. Researchers have been focused on characterizing the structure and function of TWSG1 through recombinant protein studies, which aim to elucidate its precise mechanisms of action in BMP signaling pathways. The exploration of TWSG1 as a therapeutic target is also gaining traction, as understanding its interactions could pave the way for novel interventions in conditions stemming from aberrant BMP signaling. Overall, the investigation of TWSG1 recombinant protein not only enhances our comprehension of fundamental developmental processes but also holds potential implications for clinical applications in regenerative medicine and oncology.
