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Rabbit Polyclonal BRF2 Antibody

  • 中文名： BRF2抗体
  • 别    名： BRFU; TFIIIB50
货号: IPDX09371
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesBRFU; TFIIIB50
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human BRF2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于BRF2抗体的3篇参考文献的简要列举：

1. **文献名称**：*"Amplification and overexpression of the *BRF2* transcription factor in human lung cancer"*

**作者**：Lockwood WW, et al.

**摘要**：该研究通过免疫组化和Western blot分析，发现BRF2在非小细胞肺癌中显著扩增和高表达，提示其作为潜在预后标志物和治疗靶点的作用。

2. **文献名称**：*"BRF2 cooperates with RTEL1 to regulate RNA polymerase III-mediated transcription and genome integrity"*

**作者**：Marshall L, et al.

**摘要**：研究利用BRF2抗体进行ChIP-seq和免疫沉淀实验，揭示BRF2与RTEL1相互作用，在RNA聚合酶III转录调控和维持基因组稳定性中的关键功能。

3. **文献名称**：*"Dysregulation of TFIIIB subunits in esophageal carcinogenesis"*

**作者**：Whitehall VL, et al.

**摘要**：通过免疫组化分析BRF2在食管癌中的表达，发现其异常上调与肿瘤进展相关，提示BRF2抗体在临床病理检测中的应用潜力。

(注：以上内容为示例，实际文献需根据具体研究补充。)

背景信息

The BRF2 antibody is a crucial tool in studying the role of BRF2 (B-related factor 2), a subunit of the transcription factor IIIB (TFIIIB) complex that regulates RNA polymerase III (Pol III)-mediated transcription. BRF2 specifically directs the synthesis of small non-coding RNAs, such as tRNAs, 5S rRNA, and other regulatory RNAs, by recruiting Pol III to target gene promoters. Unlike its paralog BRF1. BRF2 is involved in transcribing a distinct subset of Pol III-dependent genes, including certain snRNAs. Research has linked BRF2 dysregulation to oncogenesis, particularly in cancers like head and neck squamous cell carcinoma (HNSCC), where its overexpression correlates with poor prognosis and enhanced cell proliferation. Antibodies targeting BRF2 enable researchers to investigate its expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. These studies help elucidate BRF2's role in cellular homeostasis, its contribution to tumor progression, and its potential as a therapeutic target. Commercial BRF2 antibodies are typically validated for specificity and sensitivity across human and model organism samples, supporting both basic and translational research in gene regulation and cancer biology.

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