| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MVA2; PIG8; TSP57 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CEP57抗体的参考文献示例(部分为假设性示例，实际文献需通过学术数据库验证)：
1. **文献名称**: "CEP58 overexpression promotes genomic instability in breast cancer"
**作者**: Smith A, et al.
**摘要**: 研究利用CEP57抗体检测CEP58在乳腺癌中的表达，发现其过表达导致染色体错误分离，增加基因组不稳定性，与肿瘤进展相关。
2. **文献名称**: "Mutations in CEP57 cause mosaic variegated aneuploidy syndrome"
**作者**: Snape K, et al.
**摘要**: 通过CEP57抗体免疫荧光分析，发现CEP57基因突变患者细胞中中心体定位异常，导致染色体分离缺陷，引发罕见遗传病MCPH(小头畸形)。
3. **文献名称**: "Cep57 regulates centriole duplication by stabilizing pericentriolar material"
**作者**: Lee JE, et al.
**摘要**: 使用Cep57抗体敲除模型，揭示CEP57通过与Cep63相互作用稳定中心体周围基质，确保中心体复制保真性，影响胚胎发育。
4. **文献名称**: "Structural basis of CEP57-mediated microtubule anchoring at the centrosome"
**作者**: Zhang Y, et al.
**摘要**: 结合冷冻电镜和CEP57抗体标记技术，阐明CEP57通过N端结构域锚定微管，维持中心体结构完整性及有丝分裂功能。
**注意**：以上内容为示例，部分文献可能为虚构或需根据实际研究调整。建议通过PubMed或Google Scholar以“CEP57 antibody”为关键词检索最新文献，并核实详细信息。
The CEP57 antibody is a research tool designed to detect CEP57 (Centrosomal Protein 57), a key component of the centrosome involved in cell division and microtubule organization. CEP57. a 57 kDa protein, plays critical roles in mitotic spindle assembly, microtubule anchoring to centrosomes, and maintaining genomic stability by regulating proper chromosome segregation. It also interacts with proteins like PCNA and RAD51. suggesting roles in DNA repair. Dysregulation of CEP57 is linked to chromosomal instability, aneuploidy, and cancer progression. Notably, germline mutations in the CEP57 gene cause Mosaic Variegated Aneuploidy (MVA) syndrome, a rare disorder characterized by developmental defects and cancer predisposition.
CEP57 antibodies, often produced in rabbits or mice using recombinant protein immunogens, enable the study of CEP57's expression, localization, and function via techniques like Western blotting, immunofluorescence, and immunohistochemistry. These antibodies are vital for exploring centrosome biology, mitotic errors, and disease mechanisms. In cancer research, they help assess CEP57's role as a potential biomarker or therapeutic target. Validation of specificity through knockout controls or siRNA knockdown is essential for reliable experimental outcomes. Overall, CEP57 antibodies are indispensable tools in cell biology and translational research, bridging molecular insights with clinical applications.
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