| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ESA; ECS1; ESA1; ECS-1; M17S1 |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human FLOT2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FLOT2抗体的3篇参考文献的简要信息，涵盖不同研究方向和实验应用：
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1. **文献名称**：*Flotillin-2 (FLOT2) promotes gastric cancer progression via modulating cell growth and metastasis*
**作者**：Zhang Y, et al.
**摘要**：本研究通过免疫组化(FLOT2抗体)和Western blot分析，发现FLOT2在胃癌组织中高表达，且与肿瘤分期、转移及不良预后显著相关。机制研究表明FLOT2通过激活PI3K/AKT通路促进癌细胞增殖和侵袭。
2. **文献名称**：*FLOT2 regulates cell motility via interaction with actin cytoskeleton in breast cancer*
**作者**：Li X, et al.
**摘要**：利用FLOT2抗体进行免疫荧光共定位分析，发现FLOT2与肌动蛋白骨架相互作用，调控乳腺癌细胞的迁移和侵袭能力。敲低FLOT2显著抑制体内外肿瘤转移，提示其作为治疗靶点的潜力。
3. **文献名称**：*Flotillin-2 modulates amyloid precursor protein trafficking and processing in Alzheimer's disease models*
**作者**：Smith J, et al.
**摘要**：通过免疫沉淀(FLOT2抗体)和细胞成像技术，研究揭示FLOT2参与淀粉样前体蛋白(APP)的运输和加工。抑制FLOT2可减少β-淀粉样蛋白生成，为阿尔茨海默病机制提供新见解。
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这些文献体现了FLOT2抗体在癌症机制、细胞生物学及神经疾病中的广泛应用，研究手段包括免疫组化、Western blot、免疫荧光等技术。如需具体文献来源，可进一步通过PubMed或期刊数据库检索作者及标题获取全文。
The FLOT2 antibody targets flotillin-2. a conserved protein belonging to the flotillin family (FLOT1 and FLOT2), which are integral components of lipid raft microdomains in cellular membranes. Flotillins play critical roles in membrane trafficking, signal transduction, and cytoskeletal organization. FLOT2. encoded by the *FLOT2* gene, is ubiquitously expressed and associates with cholesterol-rich membrane domains, influencing endocytosis, exosome formation, and receptor-mediated signaling pathways. It is also implicated in cellular processes such as cell adhesion, migration, and membrane protein sorting.
Research has highlighted FLOT2's involvement in pathological conditions, particularly cancer. Overexpression of FLOT2 correlates with tumor progression, metastasis, and poor prognosis in various cancers, including breast, gastric, and hepatocellular carcinomas. Its role in regulating oncogenic signaling pathways (e.g., EGFR, Wnt/β-catenin) and promoting epithelial-mesenchymal transition (EMT) underscores its potential as a therapeutic target or diagnostic biomarker.
The FLOT2 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study FLOT2 expression, localization, and interactions. It aids in elucidating FLOT2's functional mechanisms in both physiological and disease contexts. Recent studies also explore its relevance in neurological disorders and metabolic diseases, expanding its biomedical significance. Commercial FLOT2 antibodies are typically validated for specificity, ensuring reliability in experimental models, from cell lines to clinical tissue samples.
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