Rabbit Polyclonal ATMIN Antibody

The ATM interactor (ATMIN) protein, also known as ZNF822. functions as a cofactor for the ATM kinase, a key regulator of the DNA damage response (DDR). ATMIN facilitates ATM activation in response to oxidative or replication stress, particularly when DNA double-strand breaks (DSBs) are not the primary trigger. It plays a role in non-canonical ATM signaling pathways, influencing processes like chromatin remodeling and replication fork stability. ATMIN antibodies are essential tools for studying its expression, localization, and interaction networks. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to explore ATMIN's role in cellular stress responses, cancer biology, and development. Studies using these antibodies have revealed that ATMIN acts as a tumor suppressor in certain contexts (e.g., limiting replication stress in hematopoietic cells) but may exhibit oncogenic properties in others, such as promoting lung adenocarcinoma progression. ATMIN knockout models show embryonic lethality in mice, with defects in lung and heart development, underscoring its importance in organogenesis. Despite its functional overlap with ATM, ATMIN maintains distinct roles, particularly in developmental pathways and replication stress management. Researchers rely on validated ATMIN antibodies to dissect these context-dependent roles and therapeutic implications in diseases like cancer.