Rabbit Polyclonal NIP7 Antibody

NIP7 (Nucleolar Integral Protein 7) is a conserved eukaryotic protein primarily localized in the nucleolus, a subnuclear compartment critical for ribosomal RNA (rRNA) synthesis and ribosome assembly. It belongs to the BRIX family of proteins, which are involved in pre-rRNA processing during ribosome biogenesis. NIP7 plays a role in 18S rRNA maturation by facilitating the cleavage and modification steps within the small ribosomal subunit (SSU) processome. Studies suggest it interacts with other ribosome assembly factors, such as Nop56 and Nop14. forming complexes essential for proper rRNA folding and stability. Dysregulation of NIP7 has been linked to developmental defects and diseases, including cancer, as ribosome biogenesis is tightly coupled to cell proliferation. Antibodies targeting NIP7 are valuable tools for studying its expression, localization, and molecular interactions. They enable techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore its role in nucleolar dynamics, ribosomopathies, and cellular stress responses. Research using NIP7 antibodies also contributes to understanding how ribosomal dysfunction impacts genetic disorders and oncogenesis.