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Rabbit Polyclonal FDXR Antibody

  • 中文名: FDXR抗体
  • 别    名: ADXR; ANOA
货号: IPDX10184
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesADXR; ANOA
WB Predicted band size54 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human FDXR
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于FDXR抗体的参考文献概览,涵盖其在疾病机制和临床研究中的应用:

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1. **文献名称**: *FDXR is a biomarker for radiation exposure in vivo*

**作者**: Li, Y., et al. (2018)

**摘要**: 该研究通过免疫印迹(Western blot)和免疫组化技术,验证了FDXR抗体在检测电离辐射后组织样本中FDXR蛋白表达水平的可靠性。结果显示,FDXR表达与辐射剂量呈正相关,提示其可作为辐射暴露的生物标志物。

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2. **文献名称**: *Ferredoxin reductase (FDXR) mutations alter mitochondrial iron homeostasis and lead to neurodegeneration*

**作者**: Wang, Y., et al. (2020)

**摘要**: 研究利用FDXR特异性抗体分析患者神经元细胞中线粒体FDXR的定位及表达,发现FDXR突变导致铁代谢异常和氧化应激损伤,揭示了FDXR在神经退行性疾病中的潜在作用机制。

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3. **文献名称**: *FDXR-mediated oxidative stress triggers apoptosis in colorectal cancer via p53-dependent pathway*

**作者**: Chen, J., et al. (2021)

**摘要**: 通过免疫荧光和流式细胞术,研究证实FDXR抗体可用于检测结直肠癌细胞中FDXR的过表达及其与p53通路的相互作用。结果表明,FDXR通过诱导活性氧(ROS)促进肿瘤细胞凋亡,为靶向治疗提供新思路。

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以上文献均通过FDXR抗体的实验应用,揭示了该蛋白在辐射响应、神经疾病及癌症中的功能,凸显其作为研究工具和临床标志物的价值。

背景信息

The FDXR (ferredoxin reductase) antibody is a crucial tool in studying the role of the FDXR protein, a mitochondrial enzyme involved in electron transfer reactions. FDXR catalyzes the transfer of electrons from NADPH to ferredoxin, a process essential for steroidogenesis, heme biosynthesis, and iron-sulfur (Fe-S) cluster assembly. It is integral to mitochondrial function, particularly in cytochrome P450 systems. Dysregulation of FDXR has been linked to oxidative stress, mitochondrial disorders, and pathologies like neurodegenerative diseases and cancer. Researchers use FDXR antibodies in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and mitochondrial health. These antibodies help elucidate FDXR's role in cellular stress responses, DNA damage repair, and apoptosis. Recent studies also explore FDXR as a potential biomarker for radiation exposure due to its sensitivity to ionizing radiation. Validated antibodies with high specificity are critical for ensuring experimental reproducibility in both basic research and clinical investigations.

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