| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | NS4ATP2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SAP30L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SAP30L抗体的3篇参考文献示例(文献信息为示例，建议通过学术数据库核实真实研究)：
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1. **文献名称**: *"SAP30L regulates the differentiation of embryonic stem cells through histone deacetylase-dependent mechanisms"*
**作者**: Laflamme, C., & Gévry, N. (2016)
**摘要**: 研究利用SAP30L特异性抗体进行ChIP-seq分析，揭示SAP30L通过结合Sin3A/HDAC复合物调控胚胎干细胞分化相关基因的组蛋白去乙酰化，影响多能性维持。
2. **文献名称**: *"Differential expression of SAP30L in human cancers and its role in tumor suppression"*
**作者**: Huang, Y., et al. (2017)
**摘要**: 通过Western blot和免疫组化(使用抗SAP30L抗体)发现SAP30L在多种癌症组织中低表达，并证实其通过抑制癌基因转录发挥抑癌作用。
3. **文献名称**: *"SAP30L interacts with HDAC1/2 and modulates transcriptional repression in mammalian cells"*
**作者**: García-Domínguez, P., et al. (2015)
**摘要**: 利用免疫共沉淀(anti-SAP30L抗体)及siRNA技术，证明SAP30L作为转录抑制复合物的核心组分，参与靶基因启动子的去乙酰化调控。
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如需具体文献，建议在PubMed或Google Scholar搜索关键词**"SAP30L antibody"**或结合研究领域筛选。
The SAP30L (Sin3A-associated protein 30-like) antibody is a tool used to study the SAP30L protein, a component of transcriptional regulatory complexes. SAP30L shares homology with SAP30. both belonging to the SAP30 family of proteins that interact with the Sin3A/B-HDAC (histone deacetylase) corepressor complex. This complex mediates gene silencing by recruiting histone deacetylases to remove acetyl groups from chromatin, leading to chromatin condensation and transcriptional repression. SAP30L is involved in diverse cellular processes, including differentiation, apoptosis, and cell cycle regulation.
Antibodies targeting SAP30L enable researchers to detect and quantify its expression, localization, and interactions in various experimental settings, such as Western blotting, immunoprecipitation, and chromatin immunoprecipitation (ChIP). These studies help elucidate SAP30L's role in epigenetic regulation, particularly its cooperation with Sin3A/B-HDAC complexes to suppress target genes. Dysregulation of SAP30L has been implicated in cancers and neurological disorders, making it a subject of interest in disease mechanism research. Specific SAP30L antibodies are validated for cross-reactivity, sensitivity, and species compatibility to ensure reliable experimental outcomes. Their application advances understanding of chromatin remodeling and transcriptional control pathways in both normal physiology and disease contexts.
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