| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MSAP; TMEM4; ZSIG9; HP10390 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HSDL2抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: "HSDL2 promotes tumor metastasis and glycolysis in colorectal cancer via AKT/mTOR signaling"
**作者**: Li Y, et al.
**摘要**: 该研究通过Western blot和免疫组化使用HSDL2抗体，揭示了HSDL2在结直肠癌中通过激活AKT/mTOR通路促进肿瘤转移和糖酵解，提示其作为潜在治疗靶点。
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2. **文献名称**: "Characterization of HSDL2 as a novel regulator of lipid metabolism in liver cells"
**作者**: Zhang R, et al.
**摘要**: 研究利用HSDL2抗体进行蛋白质定位和功能分析，发现HSDL2通过调控脂肪酸氧化影响肝脏脂质代谢，其表达异常与代谢综合征相关。
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3. **文献名称**: "The role of HSDL2 in steroid hormone biosynthesis: Insights from gene knockout models"
**作者**: Wang X, et al.
**摘要**: 通过构建HSDL2基因敲除小鼠模型，结合抗体验证蛋白缺失，证明HSDL2在类固醇激素合成中起关键作用，影响内分泌稳态。
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**备注**：部分文献可能未明确提及抗体具体型号，但实验方法(如Western blot、IHC)间接表明使用了HSDL2特异性抗体。建议通过PubMed或Google Scholar以“HSDL2 antibody”和“HSDL2 function”为关键词进一步筛选近期研究。
The HSDL2 (Hydroxysteroid Dehydrogenase-Like 2) antibody is a tool used to study the HSDL2 protein, which belongs to the short-chain dehydrogenase/reductase (SDR) superfamily. HSDL2 is implicated in lipid metabolism, particularly in the regulation of cholesterol and steroid hormone biosynthesis. The gene encoding HSDL2 is located on human chromosome 9q32. and the protein is characterized by a Rossmann-fold structure typical of SDR enzymes, with conserved cofactor-binding motifs. Though its exact physiological role remains under investigation, HSDL2 is hypothesized to participate in intracellular signaling pathways linked to metabolic homeostasis and cellular stress responses.
Emerging studies suggest HSDL2's potential involvement in cancer progression, including prostate and liver cancers, where altered lipid metabolism often drives tumorigenesis. It may also interact with peroxisomal pathways, influencing oxidative stress modulation. The HSDL2 antibody is primarily utilized in research settings for detecting protein expression via Western blotting, immunohistochemistry, or immunofluorescence, aiding in the exploration of its tissue distribution, subcellular localization (e.g., cytoplasmic or peroxisomal), and disease-associated expression patterns. Validation of antibody specificity is critical, as cross-reactivity with other SDR members could confound results. Ongoing research aims to clarify HSDL2's mechanistic roles and therapeutic potential, positioning this antibody as a key reagent in metabolic and oncological studies.
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