Rabbit Polyclonal MT-CYB Antibody

The MT-CYB antibody targets cytochrome b, a key component of mitochondrial Complex III (ubiquinol-cytochrome c reductase) in the electron transport chain (ETC). Encoded by the mitochondrial MT-CYB gene, cytochrome b is essential for oxidative phosphorylation, facilitating electron transfer from ubiquinol to cytochrome c while contributing to proton gradient formation. As a multi-pass transmembrane protein, it plays a critical role in cellular energy production. MT-CYB antibodies are widely used in research to study mitochondrial function, ETC dynamics, and metabolic disorders. They enable detection of cytochrome b expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding investigations into mitochondrial diseases, aging, and cancer. Mutations in MT-CYB are linked to conditions such as exercise intolerance, encephalopathy, and Leber hereditary optic neuropathy (LHON). These antibodies also support research on mitochondrial DNA (mtDNA) inheritance, evolutionary biology, and cellular stress responses. Commercial MT-CYB antibodies are typically raised against conserved peptide sequences, validated for specificity across species. Their application extends to assessing mitochondrial integrity in neurodegeneration, cardiomyopathies, and drug toxicity studies, making them vital tools for exploring mitochondrial biology and pathology.