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Rabbit Polyclonal PLXNA3 Antibody

  • 中文名: PLXNA3抗体
  • 别    名: 6.3; PLXN3; PLXN4; XAP-6; HSSEXGENE
货号: IPDX12062
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/10-1/50 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/2000 Human,Mouse,Rat

产品详情

Aliases6.3; PLXN3; PLXN4; XAP-6; HSSEXGENE
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human PLXNA3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于PLXNA3抗体的参考文献示例(注:以下为模拟内容,实际文献需通过数据库验证):

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1. **文献名称**: *PLXNA3 as a Novel Biomarker in Colorectal Cancer: Immunohistochemical Analysis Using a Specific Polyclonal Antibody*

**作者**: Chen L, et al.

**摘要**: 本研究通过自制兔源多克隆抗体,利用免疫组化技术检测PLXNA3在结直肠癌组织中的表达。结果显示,PLXNA3高表达与肿瘤侵袭性和不良预后显著相关,提示其可能作为潜在治疗靶点。

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2. **文献名称**: *Plexin-A3 Modulates Neuronal Morphogenesis via Semaphorin Signaling: Evidence from Antibody Blockade Experiments*

**作者**: Tanaka K, et al.

**摘要**: 作者使用商业化PLXNA3抗体(货号abcam123)进行体外神经元培养实验,发现抗体阻断PLXNA3后显著抑制轴突导向和树突棘形成,表明其在神经发育中的关键作用。

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3. **文献名称**: *Validation of a Monoclonal Anti-PLXNA3 Antibody for Flow Cytometry and Western Blot Applications*

**作者**: Müller S, et al.

**摘要**: 本文报道了一种高特异性小鼠抗人PLXNA3单克隆抗体的开发与验证。实验证实该抗体在流式细胞术、Western blot及免疫沉淀中均表现优异,适用于肿瘤细胞表面PLXNA3的定量检测。

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4. **文献名称**: *PLXNA3 Expression in Melanoma and Its Association with Metastatic Potential*

**作者**: Rossi G, et al.

**摘要**: 通过免疫荧光和Western blot分析,研究显示PLXNA3在转移性黑色素瘤细胞中特异性高表达。使用siRNA和抗体中和实验进一步证明其通过调控MAPK通路促进肿瘤转移。

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建议通过PubMed或Google Scholar以关键词“PLXNA3 antibody” + “Western blot/immunohistochemistry”检索最新文献获取具体信息。

背景信息

The PLXNA3 antibody is a research tool targeting plexin A3. a transmembrane receptor encoded by the *PLXNA3* gene. Plexins, including PLXNA3. are critical for mediating semaphorin signaling, which regulates diverse biological processes such as axon guidance, cell migration, immune response, and angiogenesis. PLXNA3 specifically interacts with class 3 semaphorins (e.g., SEMA3A, SEMA3F) and forms complexes with neuropilins or other co-receptors to transduce signals that influence cytoskeletal dynamics and cellular adhesion. Dysregulation of PLXNA3 has been implicated in neurological disorders (e.g., autism spectrum disorders, Alzheimer’s disease), cancer progression (e.g., metastasis, tumor angiogenesis), and cardiovascular diseases. The PLXNA3 antibody enables detection and localization of the protein in tissues or cells via techniques like immunohistochemistry, Western blotting, or flow cytometry. Its applications span neuroscience, oncology, and immunology, aiding in elucidating PLXNA3's roles in disease mechanisms and potential therapeutic targeting. Recent studies also explore its involvement in synaptic plasticity and immune modulation, highlighting its multifaceted importance in cellular communication and pathophysiology.

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