| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | TB10; MIG12 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human TMSB10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于TMSB10抗体的参考文献，按作者和内容概括整理：
1. **"Thymosin β10 promotes tumor-associated macrophages M2 conversion to suppress CD8+ T-cell infiltration in lung cancer"**
- **作者**: Li X, et al.
- **摘要**: 研究利用TMSB10抗体分析其在肺癌微环境中的作用，发现TMSB10通过诱导肿瘤相关巨噬细胞向M2型极化，抑制CD8+ T细胞浸润，促进免疫逃逸。
2. **"Thymosin beta 10 is overexpressed in colorectal cancer and promotes cancer cell proliferation"**
- **作者**: Wang Y, et al.
- **摘要**: 通过TMSB10抗体检测结直肠癌组织中蛋白表达水平，证实其高表达与肿瘤增殖相关，并可能通过激活PI3K/AKT通路驱动癌症进展。
3. **"TMSB10 as a novel biomarker for diagnosis and therapeutic target in hepatocellular carcinoma"**
- **作者**: Zhang L, et al.
- **摘要**: 研究利用TMSB10抗体验证其在肝癌中的特异性表达，提出其作为肝癌诊断标志物及靶向治疗潜在靶点的价值，涉及调控细胞迁移和侵袭机制。
(注：以上文献为示例性概括，实际引用需以具体论文数据为准。)
Thymosin Beta 10 (TMSB10) is a small, highly conserved protein belonging to the thymosin β-family, primarily known for its role in regulating actin dynamics within cells. It influences cell motility, cytoskeletal organization, and intracellular signaling pathways. TMSB10 is widely expressed in various tissues, including the brain, placenta, and immune cells, and has been implicated in diverse physiological and pathological processes, such as cancer progression, neurodevelopment, and inflammatory responses. In cancer, TMSB10 is often overexpressed in tumors like glioblastoma, breast, and ovarian cancers, where it promotes cell proliferation, migration, and metastasis, making it a potential biomarker or therapeutic target.
TMSB10 antibodies are immunological tools designed to detect and quantify TMSB10 protein levels in research and diagnostic applications. These antibodies are critical for techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), enabling researchers to study TMSB10's spatial expression, regulation, and interaction partners. Polyclonal and monoclonal TMSB10 antibodies are available, typically raised in hosts like rabbits or mice. Validation of specificity and sensitivity is essential, as cross-reactivity with homologous family members (e.g., TMSB4X) may occur. Recent studies using TMSB10 antibodies have highlighted its role in neurodegenerative diseases and neural regeneration, expanding its relevance beyond oncology. Such antibodies also hold promise in developing diagnostic assays or targeted therapies, particularly in cancers with TMSB10-driven pathways.
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