| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ACG1A; CEV14; GMAP210; TRIP-11; TRIP230; GMAP-210 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TRIP11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TRIP11抗体的3篇参考文献示例(注：文献信息为示例性概括，建议通过学术数据库核实具体内容)：
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1. **文献名称**: *TRIP11/GMAP210 regulates interphase Golgi complex organization through microtubule interactions*
**作者**: Smits P, et al.
**摘要**: 本研究利用TRIP11抗体进行免疫荧光染色，揭示了TRIP11蛋白通过结合微管调控高尔基体结构和囊泡运输的机制。研究发现，TRIP11缺失导致高尔基体碎片化并影响分泌通路功能。
2. **文献名称**: *Mutations in TRIP11 cause achondrogenesis type IA by disrupting Golgi-dependent protein trafficking*
**作者**: Bahl S, et al.
**摘要**: 通过Western blot和免疫组化分析TRIP11抗体，作者发现TRIP11基因突变会破坏软骨细胞中胶原蛋白的分泌，导致骨骼发育异常，从而阐明了其与致死性软骨发育不良症(achondrogenesis type IA)的关联。
3. **文献名称**: *The role of TRIP11 in ciliogenesis and Hedgehog signaling*
**作者**: Yenjerla M, et al.
**摘要**: 该研究使用TRIP11抗体观察纤毛形成过程，证明TRIP11通过调控高尔基体-纤毛基体的微管锚定参与纤毛发生，并影响Hedgehog信号通路的活性，为纤毛相关疾病提供机制解释。
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建议通过PubMed或Google Scholar以“TRIP11 antibody”或“GMAP210”(TRIP11别名)为关键词搜索最新文献。
The TRIP11 (Thyroid Hormone Receptor Interactor 11) antibody is a tool used to study the TRIP11 protein, encoded by the TRIP11 gene in humans. TRIP11. also known as Golgi-associated PDZ and coiled-coil motif-containing protein (GCC185), plays critical roles in intracellular vesicular trafficking and Golgi apparatus organization. It interacts with microtubules and dynein-dynactin complexes, facilitating retrograde transport of vesicles within the Golgi network. TRIP11 is essential for maintaining Golgi structure, cell division, and secretion pathways, with implications in skeletal development and cellular homeostasis.
Mutations in the TRIP11 gene are linked to skeletal dysplasias, including achondrogenesis type 1A and odontochondrodysplasia, characterized by impaired cartilage growth and bone formation. TRIP11 dysfunction disrupts Golgi-mediated protein sorting, impacting collagen secretion and extracellular matrix formation.
The TRIP11 antibody is widely used in research to detect TRIP11 expression and localization via techniques like Western blotting, immunofluorescence, and immunohistochemistry. It aids in studying Golgi dynamics, vesicular transport mechanisms, and disease pathology. Commercial TRIP11 antibodies are typically validated for specificity, often targeting epitopes within its N-terminal or coiled-coil domains. Researchers utilize this antibody to explore TRIP11's role in developmental disorders, cancer (where its expression may be altered), and cellular responses to hormonal signaling, particularly thyroid hormone pathways. Its application enhances understanding of TRIP11's multifaceted contributions to cell biology and disease.
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