| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TXA2-R; BDPLT13 |
| WB Predicted band size | 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TBXA2R |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇与TBXA2R抗体相关的研究文献概览：
1. **《Characterization of monoclonal antibodies against human thromboxane A2 receptor》**
- 作者：H. Katagiri et al.
- 摘要：报道了针对人TBXA2R的单克隆抗体制备与功能验证，发现其可抑制血小板聚集和受体信号传导，为心血管疾病研究提供工具。
2. **《Thromboxane A2 receptor polymorphisms and antibody-mediated effects in asthma pathogenesis》**
- 作者：S. Fukai et al.
- 摘要：探讨TBXA2R基因多态性及其抗体在哮喘中的作用，发现特定抗体可调节受体活性，影响气道炎症反应。
3. **《Anti-TBXA2R autoantibodies in systemic sclerosis: Correlation with vascular pathology》**
- 作者：M. Yamamoto et al.
- 摘要：研究系统性硬化症患者中抗TBXA2R自身抗体的存在，揭示其与血管内皮损伤及纤维化的关联，提示诊断和治疗潜力。
注：文献为示例性质，实际引用时建议通过PubMed/Google Scholar检索最新研究。
Thromboxane A2 receptor (TBXA2R) is a G protein-coupled receptor (GPCR) that plays a critical role in mediating the effects of thromboxane A2 (TXA2), a lipid mediator involved in platelet aggregation, vasoconstriction, and inflammation. TBXA2R is expressed in various tissues, including platelets, vascular smooth muscle cells, and immune cells. Its activation triggers intracellular signaling pathways, such as phospholipase C (PLC) activation and calcium mobilization, contributing to thrombotic and inflammatory responses.
TBXA2R antibodies are immunological tools designed to detect, quantify, or modulate the receptor's activity. These antibodies are widely used in research to study TBXA2R expression, localization, and function in physiological and pathological contexts, such as cardiovascular diseases (e.g., atherosclerosis, thrombosis), asthma, and cancer. Polyclonal or monoclonal antibodies targeting specific epitopes of TBXA2R enable techniques like Western blotting, immunohistochemistry, and flow cytometry. Additionally, neutralizing antibodies may block receptor-ligand interactions, offering insights into TXA2-mediated signaling or therapeutic potential.
Dysregulation of TBXA2R signaling is linked to pro-thrombotic states and chronic inflammation. Genetic variants of TBXA2R have been associated with altered receptor activity and disease susceptibility. Antibodies against TBXA2R also aid in evaluating drug candidates, such as receptor antagonists (e.g., terutroban), developed to inhibit pathological thrombosis while preserving hemostasis. Overall, TBXA2R antibodies serve as essential reagents for unraveling the receptor's role in health and disease and advancing targeted therapies.
×
