Rabbit Polyclonal FYN Antibody

FYN antibody is a crucial tool in studying the non-receptor tyrosine kinase FYN, a member of the Src family kinases (SFKs). FYN plays diverse roles in cellular signaling, particularly in T-cell receptor activation, cell adhesion, growth, and differentiation. It exists as two isoforms (FYN-A and FYN-B) generated by alternative splicing, with varying expression in immune cells and the central nervous system. In the brain, FYN regulates synaptic plasticity, myelination, and interactions with proteins like Tau, linking it to Alzheimer’s disease pathology, where it exacerbates amyloid-β toxicity. FYN antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to detect FYN expression, phosphorylation status, or interactions in biological samples. These antibodies help elucidate FYN's involvement in diseases, including cancers (e.g., glioblastoma, leukemia), neurological disorders, and autoimmune conditions. Commercial FYN antibodies are typically monoclonal or polyclonal, validated for specificity across human, mouse, and rat models. Research using FYN antibodies has highlighted its dual role as both a tumor suppressor and promoter, depending on cellular context. Dysregulated FYN signaling is also implicated in schizophrenia and Parkinson’s disease. Developing selective FYN inhibitors remains an active therapeutic area, underscoring the antibody's importance in target validation and mechanistic studies.