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Rabbit Polyclonal ZIC1 Antibody

  • 中文名: ZIC1抗体
  • 别    名: ZIC; ZNF201
货号: IPDX12839
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/40-1/250 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesZIC; ZNF201
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human ZIC1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于ZIC1抗体的3篇参考文献的简要总结(基于公开文献整理,非真实引用,仅供参考):

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1. **文献名称**:*ZIC1 Antibody Validation in Developmental and Cancer Models*

**作者**:Smith A, et al.

**摘要**:研究验证了ZIC1抗体在小鼠胚胎组织和人类髓母细胞瘤样本中的特异性,证实其在免疫组化和Western blot中的可靠性,并发现ZIC1在神经管发育及肿瘤发生中的差异表达。

2. **文献名称**:*ZIC1 as a Biomarker in Medulloblastoma: Antibody-Based Detection*

**作者**:Lee J, et al.

**摘要**:通过商业化ZIC1抗体对儿童髓母细胞瘤样本进行检测,发现ZIC1高表达与特定分子亚型(如SHH型)相关,提示其作为诊断标志物的潜在价值。

3. **文献名称**:*Epigenetic Regulation of ZIC1 in Colorectal Cancer: Immunohistochemical Analysis*

**作者**:Wang Y, et al.

**摘要**:利用ZIC1抗体分析结直肠癌组织,发现ZIC1表达缺失与DNA甲基化相关,且低表达患者预后较差,表明其抑癌基因作用及临床意义。

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**注**:以上文献信息为示例,实际引用请通过PubMed或SciHub等平台检索关键词“ZIC1 antibody”或“ZIC1 immunohistochemistry”获取真实论文。

背景信息

ZIC1 (Zinc Finger Protein of the Cerebellum 1) is a transcription factor belonging to the ZIC family, characterized by C2H2-type zinc finger domains. It plays critical roles in embryonic development, particularly in neural tube formation, cerebellar development, and neurogenesis. Dysregulation of ZIC1 has been linked to neurological disorders and cancers, including medulloblastoma and endometrial cancer.

ZIC1 antibodies are immunological tools designed to detect and quantify ZIC1 protein expression in research and diagnostic settings. These antibodies are typically generated using immunogenic peptides derived from conserved regions of the ZIC1 protein, such as the N-terminal or zinc finger domains. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP) to study ZIC1's expression patterns, subcellular localization, and DNA-binding activity.

In research, ZIC1 antibodies help elucidate its role in developmental biology and tumorigenesis. For example, they have been employed to identify ZIC1 overexpression in certain cancers, suggesting its potential as a biomarker or therapeutic target. Validation of ZIC1 antibodies includes testing specificity via knockout cell lines or siRNA silencing. Commercial ZIC1 antibodies vary in host species (rabbit, mouse) and clonality (monoclonal/polyclonal), with applications tailored to experimental needs. Proper controls are essential to ensure accurate interpretation, given potential cross-reactivity with other ZIC family members.

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