关键信息
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基因名
LOX
- 应用
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别名
Lysyl oxidase (Ras excision protein) (Rrg)
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种属
Mouse
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表达系统
Baculovirus
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标签
C- His-Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P28301
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表达区间
163-411aa
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分子量
32.4
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
LOX (Lysyl oxidase) is a copper-dependent enzyme that plays a crucial role in the cross-linking of collagen and elastin, thereby influencing the structural integrity and mechanical properties of extracellular matrix (ECM) in various tissues. Its function is pivotal in processes such as tissue remodeling, wound healing, and fibrosis. Dysregulation of LOX activity has been implicated in various pathological conditions, including cancer progression, cardiovascular diseases, and fibrotic disorders. Consequently, LOX has emerged as a potential therapeutic target. Research endeavors have focused on the molecular mechanisms regulating LOX expression and activity, as well as its role in disease progression. Recombinant LOX proteins have been developed to facilitate studies on enzyme kinetics, substrate specificity, and interactions with ECM components. Moreover, these recombinant proteins are utilized in the development of biomaterials and tissue engineering applications, aiming to harness LOX's ability to enhance ECM stability and promote tissue regeneration. Overall, the investigation of LOX and its recombinant forms provides valuable insights into its biological functions and therapeutic potentials in addressing various health challenges.
