首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal VAMP4 Antibody

  • 中文名： VAMP4抗体
  • 别    名： VAMP-4; VAMP24
货号: IPDX12892
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/40-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesVAMP-4; VAMP24
WB Predicted band size16 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human VAMP4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

参考文献

以下是关于VAMP4抗体的3篇示例参考文献(内容为模拟概括，仅供参考)：

1. **文献名称**：*VAMP4 regulates synaptic maturation and vesicle trafficking in hippocampal neurons*

**作者**：Li, X., et al.

**摘要**：该研究利用特异性VAMP4抗体，通过免疫荧光和Western blot分析，发现VAMP4在海马神经元突触成熟过程中起关键作用，调控突触囊泡的靶向运输和释放。

2. **文献名称**：*Role of VAMP4 in Golgi-to-endosome transport mediated by the retromer complex*

**作者**：Steinberg, F., et al.

**摘要**：通过VAMP4抗体的免疫沉淀实验，作者揭示了VAMP4与逆转运复合体(retromer)的相互作用，证明其在高尔基体到内体逆向运输中调控货物蛋白分选。

3. **文献名称**：*Dysregulation of VAMP4 expression in Alzheimer’s disease models*

**作者**：Chen, Y., et al.

**摘要**：研究利用VAMP4抗体检测阿尔茨海默病模型小鼠脑组织，发现VAMP4表达水平异常升高，可能与淀粉样蛋白异常沉积导致的囊泡运输障碍相关。

**建议**：实际文献可通过PubMed或Google Scholar搜索关键词“VAMP4 antibody”或“VAMP4 function”获取，并筛选应用该抗体的实验研究。

背景信息

VAMP4 (vesicle-associated membrane protein 4) is a member of the SNARE protein family that mediates intracellular vesicle trafficking and membrane fusion. Primarily localized to the trans-Golgi network and endosomes, it plays a critical role in regulating secretory pathways, lysosomal sorting, and synaptic vesicle recycling. VAMP4 antibodies are immunological tools designed to detect and study this protein’s expression, localization, and function. These antibodies are typically generated using immunogenic peptides or recombinant VAMP4 fragments as antigens, often in hosts like rabbits or mice. Validated for applications such as Western blotting, immunofluorescence, and immunoprecipitation, they enable researchers to investigate VAMP4’s interaction with other SNARE proteins (e.g., syntaxins) and its involvement in neurological disorders, endocrine secretion, or cancer metastasis. Recent studies highlight VAMP4’s relevance in neurodegenerative diseases like Alzheimer’s, where disrupted vesicle transport contributes to pathology, and in diabetes, where insulin granule exocytosis is impaired. Commercial VAMP4 antibodies are often characterized for species reactivity (human, mouse, rat) and tested for specificity using knockout controls. Proper validation remains essential due to potential cross-reactivity with homologous VAMP isoforms (e.g., VAMP1-3).

客户数据及评论

折叠内容

大包装询价

×