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Rabbit Polyclonal ALX4 Antibody

  • 中文名： ALX4抗体
  • 别    名： CRS5; FND2
货号: IPDX13247
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesCRS5; FND2
WB Predicted band size44 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human ALX4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于ALX4抗体的3篇参考文献示例(注：以下文献信息为模拟示例，实际引用需核实原文)：

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1. **文献名称**：*ALX4 regulates cranial suture closure through mesenchymal cell differentiation*

**作者**：Johnson M, et al.

**摘要**：研究利用ALX4特异性抗体进行小鼠胚胎组织的免疫组化分析，发现ALX4通过调控间充质细胞成骨分化影响颅缝闭合，缺失导致颅面畸形。

2. **文献名称**：*Downregulation of ALX4 in colorectal cancer correlates with metastatic potential*

**作者**：Wang Y, et al.

**摘要**：通过ALX4抗体检测结直肠癌组织样本，发现ALX4蛋白表达降低与淋巴结转移和不良预后显著相关，提示其抑癌作用。

3. **文献名称**：*ALX4 antibody-based characterization of limb bud development in vertebrates*

**作者**：Garcia S, et al.

**摘要**：研究采用ALX4抗体进行鸡和小鼠肢芽的免疫荧光染色，揭示ALX4在前肢形态发生中的时空表达模式及其与SHH信号通路的相互作用。

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如需实际文献，建议在PubMed或Google Scholar检索关键词“ALX4 antibody”、“ALX4 immunohistochemistry”等，并筛选涉及实验应用的论文。

背景信息

The ALX4 (Aristaless-like homeobox 4) antibody is a tool used to detect the ALX4 protein, a transcription factor critical in embryonic development and tissue patterning. ALX4 belongs to the paired-class homeodomain protein family, playing roles in craniofacial formation, limb development, and hair follicle regeneration by regulating gene expression. It is expressed in mesenchymal cells and epithelial-mesenchymal interfaces during embryogenesis. Dysregulation of ALX4 has been linked to congenital disorders like frontonasal dysplasia and parietal foramina, as well as cancers (e.g., osteosarcoma, breast cancer), where it may act as a tumor suppressor or oncogene depending on context. The antibody, typically raised in rabbits or mice, enables research applications such as Western blotting, immunohistochemistry, and immunofluorescence to study ALX4's spatial-temporal expression, interactions, and mechanisms in development/disease. Commercial ALX4 antibodies are often validated for specificity against conserved epitopes across human, mouse, and rat homologs. Its utility spans basic developmental biology and clinical research, particularly in understanding skeletal malformations and cancer pathways.

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