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Rabbit Polyclonal CTNND2 Antibody

  • 中文名： CTNND2抗体
  • 别    名： GT24; NPRAP
货号: IPDX13256
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesGT24; NPRAP
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human CTNND2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CTNND2抗体的3篇参考文献示例(注：以下为模拟内容，具体文献需根据实际数据库检索验证)：

1. **文献名称**：*CTNND2 regulates neural progenitor cell dynamics and cortical neurogenesis*

**作者**：Smith A, et al.

**摘要**：研究利用CTNND2抗体进行免疫荧光染色，发现CTNND2在小鼠大脑皮层神经前体细胞中高表达，调控其增殖与分化，提示其在神经发育中的作用。

2. **文献名称**：*Delta-catenin (CTNND2) promotes breast cancer metastasis through EGFR signaling*

**作者**：Chen L, et al.

**摘要**：通过Western blot和免疫组化(使用CTNND2抗体)，证实CTNND2在乳腺癌组织中过表达，并通过EGFR通路增强肿瘤细胞的侵袭能力。

3. **文献名称**：*CTNND2 mutations associated with autism impair synaptic protein interactions*

**作者**：Wang Y, et al.

**摘要**：研究利用CTNND2抗体进行免疫共沉淀实验，发现自闭症相关突变导致CTNND2与突触蛋白(如PSD-95)的相互作用异常，影响神经元突触功能。

如需具体文献，建议通过PubMed或Google Scholar检索关键词“CTNND2 antibody”或“CTNND2 immunohistochemistry”获取最新研究。

背景信息

The CTNND2 antibody is a research tool targeting the CTNND2 protein (Catenin Delta-2), also known as δ-catenin, a member of the armadillo repeat protein family. CTNND2 is primarily expressed in the brain and plays roles in cell-cell adhesion, synaptic plasticity, and neural development. It interacts with cadherins and other catenins (e.g., β-catenin) to regulate cytoskeletal dynamics and signaling pathways. CTNND2 has been linked to neurodevelopmental disorders, particularly autism spectrum disorders (ASD), as mutations or deletions in the CTNND2 gene are associated with intellectual disability and ASD susceptibility. In cancer research, CTNND2 overexpression or dysregulation has been implicated in tumor progression and metastasis, though its mechanisms remain under investigation. The CTNND2 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein expression, localization, and interactions in both neurological and oncological contexts. Its development has facilitated insights into CTNND2's dual roles in neural homeostasis and disease pathogenesis, making it a critical reagent for exploring molecular pathways in development and disease.

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