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Rabbit Polyclonal TAB1 Antibody

  • 中文名： TAB1抗体
  • 别    名： 3'-Tab1; MAP3K7IP1
货号: IPDX13881
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

Aliases3'-Tab1; MAP3K7IP1
WB Predicted band size55 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human TAB1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇涉及TAB1抗体的研究文献及其摘要概括：

1. **《TAK1 regulates caspase 1 activation in macrophages during inflammation》**

- 作者：Sakurai, H., et al.

- 摘要：研究通过TAB1抗体阻断实验，揭示TAB1-TAK1复合物在巨噬细胞中激活caspase-1的机制，证实其在炎症反应中的调控作用。

2. **《TAB1 modulates cardiomyocyte apoptosis in diabetic cardiomyopathy via p38 MAPK pathway》**

- 作者：Liu, Y., et al.

- 摘要：利用TAB1抗体进行Western blot和免疫共沉淀分析，发现高糖环境下TAB1通过激活p38 MAPK信号通路促进心肌细胞凋亡，为糖尿病心肌病提供机制解释。

3. **《Structural insights into the interaction of TAK1 with TAB1》**

- 作者：Xiao, Y., et al.

- 摘要：通过TAB1抗体介导的蛋白质互作分析，解析TAK1-TAB1复合物的结构特征，阐明其介导细胞应激信号传导的分子基础。

注：以上文献为示例，实际引用时建议通过PubMed或Web of Science核对最新研究。

背景信息

The TAB1 (TAK1-binding protein 1) antibody is a key tool for studying the TAB1 protein, a critical adaptor molecule in cellular signaling pathways. TAB1 interacts with TAK1 (transforming growth factor-β-activated kinase 1) to form a complex that activates downstream signaling cascades, including NF-κB and MAPK pathways, which regulate inflammation, immune responses, and stress responses. This interaction is essential for mediating signals from receptors like IL-1R, TNF-R, and Toll-like receptors. TAB1 antibodies are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to detect TAB1 expression, localization, and protein-protein interactions in various biological samples. Researchers employ these antibodies to investigate TAB1's role in diseases, including cancer, neurodegenerative disorders, and autoimmune conditions, where dysregulated TAK1-TAB1 signaling is implicated. Most TAB1 antibodies are raised in hosts like rabbits or mice, targeting specific epitopes (e.g., human TAB1 residues 300-400). Validation includes testing for specificity via knockout controls or siRNA knockdown. Commercial TAB1 antibodies often come with data demonstrating reactivity across species (human, mouse, rat) and applications. Their utility extends to both basic research and drug discovery, particularly in studying pathways involved in inflammation and apoptosis.

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