关键信息
-
基因名
C1D
-
简介
The C1D protein has multifunctionality in cellular processes, recruiting RNA exosome complexes for 5.8S rRNA processing, possibly in conjunction with MPHOSPH6. It activates PRKDC with linear and supercoiled DNA and induces apoptosis through the p53/TP53 pathway. C1D Protein, Human (His) is the recombinant human-derived C1D protein, expressed by E. coli , with N-GST labeled tag.
- 应用
-
别名
Nuclear nucleic acid-binding protein C1D; hC1D; C1D
-
种属
Human
-
表达系统
E. coli
-
标签
N-6*His
-
纯度
Greater than 95% as determined by SDS-PAGE.
-
蛋白编号
Q13901
-
表达区间
M1-S141
-
蛋白长度
Full Length
-
分子量
18 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
C1D protein, a member of the C1D family of proteins, has garnered attention in molecular biology and biomedical research due to its multifunctional roles in cellular processes. Initially identified for its involvement in the regulation of gene expression, C1D is known to interact with DNA and RNA, suggesting a role in transcriptional regulation and nuclear processes. Recent studies have highlighted its significance in various cellular pathways, including stress response and apoptosis, making it a potential focus in cancer research and therapy. Furthermore, C1D has been implicated in the modulation of chromatin structure, which is essential for gene accessibility and expression. Its expression levels have been correlated with several malignancies, indicating its potential as a biomarker for diagnosis and prognosis. The recombinant version of C1D protein has become an important tool for elucidating its biochemical properties and physiological functions. By utilizing advanced techniques in protein engineering and purification, researchers are exploring C1D's roles in cellular signaling pathways and its interactions with other cellular components. Understanding the mechanisms by which C1D operates could unveil novel therapeutic strategies for diseases where these pathways are disrupted, thereby addressing significant gaps in current medical treatments. As research on C1D protein continues to unfold, it holds promise not only for expanding our understanding of cellular biology but also for its application in developing targeted therapeutic interventions.
