关键信息
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基因名
GBP2
- 应用
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别名
GTP-binding protein 2; Guanine nucleotide-binding protein 2
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种属
Rat
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q63663
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表达区间
Asn35~Ala276
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分子量
31kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GBP2, or Guanylate Binding Protein 2, is a crucial member of the GBP family, which plays a significant role in the immune response, particularly against intracellular pathogens such as viruses and certain bacteria. The study of GBP2 has gained traction in recent years due to its involvement in various immune regulatory processes, including the modulation of cytokine responses and the enhancement of autophagy. GBP2 can recognize and bind to specific guanosine triphosphates, leading to its activation and subsequent action in promoting host defense mechanisms. Notably, research has indicated that GBP2 is upregulated in response to interferon stimulation, highlighting its importance in the host's defense against infections. Given its potential therapeutic implications, understanding the structure-function relationship of GBP2 is vital for developing novel strategies to enhance immune responses or treat inflammatory diseases. Recent studies have focused on the molecular characterization and functional roles of GBP2, revealing its potential as a target for drug development in immunomodulatory therapies. As research continues, GBP2 is positioned as an important component of the innate immune response, warranting further investigation to explore its full potential in combatting infectious diseases and modulating immune pathways.
