关键信息
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基因名
Aconitase 2/ACO2
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简介
Aconitase 2/ACO2 Protein, an enzyme, plays a vital role in the tricarboxylic acid cycle and energy production. Dysregulation of Aconitase 2/ACO2 Protein has been associated with mitochondrial dysfunction and oxidative stress. Targeting Aconitase 2/ACO2 Protein may provide potential therapeutic strategies by regulating energy metabolism, reducing oxidative damage, and improving mitochondrial function. Aconitase 2/ACO2 Protein, Human (sf9, His-GST) is the recombinant human-derived Aconitase 2/ACO2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- 应用
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别名
Aconitate hydratase; Aconitase; ACO2
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种属
Human
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表达系统
Baculovirus
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标签
N-His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99798
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表达区间
Q28-Q780
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蛋白长度
Full Length of Mature Protein
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分子量
110 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Aconitase 2 (ACO2) is a crucial enzyme involved in the citric acid cycle, primarily located in the mitochondria, and plays a significant role in cellular metabolism and energy production. The enzyme catalyzes the reversible conversion of citrate to isocitrate, facilitating crucial metabolic processes. Recent research has highlighted ACO2's involvement in cellular homeostasis and its regulation of iron metabolism, linking it to various physiological and pathological conditions, including neurodegenerative diseases and cancer. Understanding ACO2's structure and function is essential for deciphering its role in these conditions, which has prompted extensive studies on its recombinant protein form. Producing ACO2 as a recombinant protein allows for detailed biochemical and biophysical characterization, enabling researchers to investigate its enzymatic activity, regulatory mechanisms, and interactions with other biomolecules. Additionally, the availability of recombinant ACO2 opens avenues for potential therapeutic applications aimed at modulating its function in diseases associated with mitochondrial dysfunction. Thus, the study of ACO2 recombinant protein is not only pivotal for basic science but also holds promise for translational research aiming to develop targeted therapies for metabolic and oxidative stress-related disorders.
