关键信息
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基因名
HOXA1
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简介
The HOXA1 protein is a sequence-specific transcription factor that complexly regulates multiple developmental processes in the brainstem, inner and outer ears, abducens nerves, and cardiovascular development. It also plays a key role in cognitive and behavioral processes. HOXA1 Protein, Human (His) is the recombinant human-derived HOXA1 protein, expressed by E. coli , with N-His labeled tag.
- 应用
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别名
Homeobox protein Hox-A1; HOXA1; HOX1F
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49639-1
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表达区间
M1-H335
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蛋白长度
Full Length of Isoform-1
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分子量
42 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
HOXA1 is a member of the homeobox gene family, which plays a crucial role in embryonic development and cellular differentiation. Research has shown that HOXA1 is involved in various biological processes, including the regulation of development in the central nervous system, limb formation, and hematopoiesis. Dysregulation of HOXA1 expression has been implicated in several diseases, particularly cancers and neurodevelopmental disorders. As a transcription factor, HOXA1 functions by binding to specific DNA sequences, thereby influencing the expression of downstream target genes. Understanding the molecular mechanisms of HOXA1 activity is essential for elucidating its role in normal development and disease. The production of recombinant HOXA1 protein allows for detailed biochemical studies, including its interaction with other proteins and its functionality in various cellular contexts. By characterizing the structure and function of HOXA1, researchers aim to uncover its potential as a therapeutic target and its contributions to pathophysiological conditions. The study of HOXA1 recombinant protein forms a vital foundation for advancing our knowledge of developmental biology and therapeutic interventions for HOXA1-related diseases.
