Cat: IPD-X41001

Recombinant Human NR4A2 Protein (Yeast),His

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  • 规格
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关键信息

  • 基因名

    NR4A2

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    Immediate-early response protein NOT Orphan nuclear receptor NURR1 Transcriptionally-inducible nuclear receptor NOT, NURR1, TINUR

  • 种属

    Human

  • 表达系统

    Yeast

  • 标签

    N- His

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P43354

  • 表达区间

    1-598aa

  • 分子量

    68.6 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

NR4A2, also known as Nuclear Receptor Subfamily 4 Group A Member 2, is a transcription factor that belongs to the nuclear receptor family, playing a pivotal role in various biological processes, including neurodevelopment, metabolism, and immune response. Research has increasingly focused on NR4A2 due to its involvement in neurodegenerative diseases, particularly Parkinson's disease, where its expression is altered and linked to neuronal survival and apoptosis. Furthermore, NR4A2 is implicated in the regulation of several genes related to inflammation and oxidative stress, making it a potential target for therapeutic interventions. As a result, the study of NR4A2 recombinant proteins has garnered significant interest, as these proteins can be utilized to elucidate its mechanisms of action, interactions with other cellular components, and regulatory pathways. Understanding NR4A2 function at a molecular level may lead to the development of novel treatments aimed at restoring its activity or mitigating its dysregulation in disease states. The use of recombinant NR4A2 also facilitates high-throughput screening of small molecules that could modulate its activity, opening avenues for drug discovery and contributing to the growing field of targeted therapy in neurodegenerative and inflammatory diseases.

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