Cat: IPD-X38729

Recombinant Mouse ABCA5 Protein,His

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关键信息

  • 基因名

    ABCA5

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    ABC-A5

  • 种属

    Mouse

  • 表达系统

    E. coli

  • 标签

    N-His

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q8K448

  • 表达区间

    Val1401~Phe1642

  • 分子量

    32kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

ABCA5 is a member of the ATP-binding cassette (ABC) transporter family, and its significance has been increasingly recognized in recent years due to its potential role in lipid metabolism, especially in the context of lipid transport and cellular cholesterol homeostasis. ABCA5 is predominantly expressed in macrophages and tissues such as the brain, indicating its involvement in crucial biological processes, including immune response and neural function. Studies have suggested that ABCA5 may influence the accumulation of lipids and modulate the inflammatory response, making it a candidate for understanding various diseases, including atherosclerosis, Alzheimer's disease, and metabolic disorders. The recombinant expression of ABCA5 enables researchers to investigate its functional properties, interactions with lipids, and regulatory mechanisms. Moreover, by studying the protein’s structure and function through recombinant techniques, scientists aim to elucidate its precise role in cellular processes and its potential as a therapeutic target. Given the growing evidence linking ABCA5 to important physiological and pathological processes, ongoing research endeavors focus on understanding its molecular mechanisms, which could pave the way for novel interventions in related diseases. These insights could lead to the development of new strategies for modulating lipid metabolism and improving health outcomes in conditions characterized by dysregulated lipid dynamics.

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