关键信息
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基因名
CNTNAP3
- 应用
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别名
CASPR3; CNTNAP3A; Cell recognition molecule Caspr3
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BZ76
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表达区间
Gly26~Lys349
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分子量
66kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CNTNAP3, or Caspr-like protein 3, is a member of the neurexin superfamily, which is critical for neuronal development and synaptic function. Research indicates that CNTNAP3 plays an essential role in the formation and maintenance of the axo-glial junctions in the nervous system, facilitating communication between neurons and glial cells. Mutations or dysregulation of CNTNAP3 have been implicated in various neurological disorders, including autism spectrum disorders and schizophrenia, highlighting its importance in neurodevelopmental processes. Recombination and expression of CNTNAP3 protein in a laboratory setting allow researchers to study its structural and functional properties, as well as its interactions with other proteins in the neural circuitry. By generating recombinant CNTNAP3, scientists can investigate its role in cell adhesion, signaling pathways, and the overall impact on synaptic plasticity. Furthermore, understanding CNTNAP3's function can potentially lead to therapeutic targets for treating neurodevelopmental disorders, making it a significant focus in neuroscience research. This ongoing investigation emphasizes the necessity of characterizing the biochemical and biophysical properties of CNTNAP3, paving the way for deeper insights into its involvement in neural connectivity and the pathophysiology of associated disorders.
