关键信息
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基因名
VAV2
- 应用
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别名
Guanine Nucleotide Exchange Factor VAV2
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P52735
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表达区间
Met1~Ser119
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分子量
15 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
VAV2, a member of the Vav family of guanine nucleotide exchange factors (GEFs), plays a critical role in regulating signaling pathways involved in cell proliferation, differentiation, and migration. Research into VAV2 has gained momentum due to its association with various physiological processes and its implications in cancer biology. VAV2 functions by activating Rho family GTPases, thereby influencing cytoskeletal dynamics and cellular responses to external stimuli. Aberrant expression and activity of VAV2 have been linked to several types of cancers, making it a potential therapeutic target. Additionally, VAV2's role in immune cell signaling highlights its importance in both innate and adaptive immunity. The molecular mechanisms by which VAV2 exerts its effects are complex, involving multiple protein-protein interactions and regulatory feedback loops. Recombinant VAV2 protein studies are crucial for elucidating its structure-function relationships and for developing potential inhibitors or modulators as therapeutic agents. Consequently, producing and characterizing recombinant VAV2 protein is essential to explore its biological activities and to better understand its involvement in disease mechanisms. This research could pave the way for novel approaches in targeted cancer therapies and immunological interventions.
