Recombinant Human WBP2 protein

**Background of WBP2 Recombinant Protein**

WBP2 (WW domain-binding protein 2) is a multifunctional adaptor protein involved in regulating cellular processes such as transcriptional activation, signal transduction, and protein-protein interactions. It was initially identified through its ability to interact with WW domain-containing proteins, including the Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), key regulators of the Hippo signaling pathway. Structurally, WBP2 contains two WW domains that mediate binding to proline-rich motifs in partner proteins, as well as a coiled-coil region and a nuclear localization signal, enabling its role in both cytoplasmic and nuclear signaling.

WBP2 has been implicated in cancer progression, particularly in breast and thyroid cancers, where it enhances oncogenic signaling pathways like Wnt/β-catenin and ERK. Its interaction with estrogen receptor alpha (ERα) further links it to hormone-responsive malignancies. Beyond cancer, WBP2 contributes to developmental processes and tissue homeostasis, with studies highlighting its role in mammary gland development and auditory function.

Recombinant WBP2 protein is engineered using expression systems (e.g., *E. coli* or mammalian cells) to produce purified, biologically active forms of the protein for research. This tool enables *in vitro* studies of WBP2’s interactions, post-translational modifications (e.g., phosphorylation), and mechanistic roles in disease pathways. Researchers also utilize it to screen for inhibitors targeting WBP2-mediated oncogenic activity, positioning it as a potential therapeutic target. The development of WBP2 recombinant protein has thus advanced our understanding of its dual roles in physiology and pathology, offering insights for translational applications.