Recombinant Human MD-2/LY96 Protein，His

MD-2/LY96

Myeloid differentiation factor-2 (MD2) (LY96 gene) is a small glycoprotein expressed by macrophages and dendritic cells. MD2 functions as a co-receptor for toll-like receptor (TLR) 4 and is required for its activation. Recognition of LPS by TLR4 requires MD-2 since most of the lipid chains of LPS interact with a hydrophobic pocket in MD-2. MD2 confers invasiveness by activating MAPK and NF-kB signaling pathways and inducing epithelial-mesenchymal transition[1][2]. MD-2/LY96 Protein, Human (His) is the recombinant human-derived MD-2/LY96 protein, expressed by E. coli , with C-10*His labeled tag.

SPR MST BLI ITC ELISA 细胞实验 药物筛选

Lymphocyte antigen 96; LY96; Ly-96; ESOP-1; Protein MD-2; ESOP1; MD2; Myeloid Differentiation Protein 2/Lymphocyte Antigen 96

Human

E. coli

C-10*His

Greater than 90% as determined by SDS-PAGE.

Q9Y6Y9-1

E17-N160

Full Length of Isoform-1 Mature Protein

19 kDa

< 1.0 EU per μg protein as determined by the LAL method.

Freeze-dried powder

PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

点位突变 标签定制 buffer定制 全长蛋白定制

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.