关键信息
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基因名
IL-1 alpha/IL-1F1
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简介
The IL-1α/IL-1F1 protein is found intracellularly in most non-hematopoietic cells and plays a crucial role in mediating inflammation and linking innate and adaptive immunity. IL1RAP binds to IL1R1 to form a high-affinity receptor complex that activates cascades and pathways.IL-1 alpha/IL-1F1 Protein, Pig is the recombinant Porcine-derived IL-1 alpha/IL-1F1 protein, expressed by E. coli , with tag free.
- 应用
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别名
Interleukin-1 alpha; IL1A; IL-1 alpha; Interleukin 1 alpha
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种属
Porcine
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P18430
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表达区间
Q119-S270
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蛋白长度
Partial
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分子量
18 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Interleukin-1 alpha (IL-1α), also known as IL-1F1, is a pro-inflammatory cytokine that plays a crucial role in immune responses and inflammation. It is primarily produced by activated macrophages and epithelial cells and is involved in various physiological processes, including cell proliferation, differentiation, and apoptosis. Dysregulation of IL-1α expression has been implicated in numerous pathological conditions, such as autoimmune diseases, rheumatoid arthritis, and cancer. The recombinant form of IL-1α has garnered significant attention in research and therapeutic applications due to its potential as a biomarker or therapeutic target. Studies on the recombinant IL-1α/IL-1F1 protein have focused on understanding its structure-function relationship, signaling pathways, and interactions with other cytokines and receptors. Additionally, its role in mediating inflammatory responses in various diseases makes it a key subject of interest for developing novel therapies aimed at modulating the immune system. Given the involvement of IL-1α in chronic inflammation and its association with severe health conditions, ongoing research aims to explore its therapeutic potential while investigating the regulatory mechanisms that govern its activity in health and disease. Consequently, generating recombinant IL-1α provides a valuable tool for elucidating its biological functions and for evaluating its efficacy in clinical settings. As therapeutic agents targeting the IL-1 pathway are being developed, understanding recombinant IL-1α's properties and mechanisms can pave the way for innovative strategies in treating inflammatory and autoimmune disorders.
