关键信息
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基因名
NKAP
- 应用
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别名
NF Kappa B Activating Protein
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种属
Rat
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q4V7C9
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表达区间
Phe273~Lys415
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分子量
22kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
NKAP (Nuclear Kappa B-Associated Protein) is a critical regulator involved in various cellular processes, including immune response, cell proliferation, and apoptosis. Research on NKAP has gained momentum due to its association with several diseases, particularly autoimmune disorders and cancers. Initially discovered as a co-regulator of NF-κB signaling, NKAP has been shown to interact with various transcription factors, influencing gene expression and cellular responses. Its role in lymphocyte development and differentiation highlights its importance in the immune system. Additionally, studies have indicated that dysregulation of NKAP is implicated in the pathogenesis of conditions like systemic lupus erythematosus and certain types of leukemia. The recombinant NKAP protein is being explored for its potential therapeutic applications and as a biomarker for disease diagnosis and prognosis. Understanding the structure and function of NKAP through recombinant methodologies facilitates the development of targeted therapies and contributes to our broader knowledge of immune regulation and cancer biology. This research not only paves the way for novel treatment strategies but also enhances our understanding of the molecular mechanisms underlying immune system disorders.
