关键信息
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基因名
RPS6Kb1
- 应用
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别名
PS6K; S6K; S6K1; STK14A; p70(S6K)-alpha; p70-S6K; p70-alpha; P70-S6 Kinase 1; 70 kDa ribosomal protein S6 kinase 1; Serine/threonine-protein kinase 14A
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P23443
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表达区间
Phe91~Phe352
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分子量
33kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
RPS6Kb1, also known as ribosomal protein S6 kinase beta-1, is a crucial component of the mTOR (mechanistic target of rapamycin) signaling pathway, which plays a vital role in cellular growth, proliferation, and survival. This serine/threonine kinase is involved in the phosphorylation of ribosomal protein S6, among other substrates, thereby influencing protein synthesis and cell metabolism. Dysregulation of RPS6Kb1 has been implicated in various diseases, including cancer and metabolic disorders, making it an important target for therapeutic intervention. Given its central role in translational control and cellular responses to growth signals, researchers focus on the recombinant expression of RPS6Kb1 to better understand its functional mechanisms and interactions within signaling networks. Studies utilizing recombinant RPS6Kb1 can provide insights into its enzymatic activities, regulatory functions, and how its dysregulation contributes to disease pathologies. Furthermore, understanding the structure-function relationships of RPS6Kb1 through recombinant protein studies can facilitate the design of specific inhibitors or modulators, opening new avenues for targeted treatments in conditions linked to mTOR pathway abnormalities. As such, the investigation of RPS6Kb1 not only enhances our knowledge of fundamental cellular processes but also holds promise for clinical applications in therapeutic strategies aimed at correcting mTOR-related disorders.
