关键信息
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基因名
TMC4
- 应用
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7Z404
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表达区间
Met1~Arg168
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分子量
49kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
TMC4, or Transmembrane Channel-like protein 4, is a member of the TMC family, which is known for its role in ion channel activities and cellular signaling. Research into TMC4 has gained momentum due to its potential implications in sensory perception, particularly in the auditory system, as well as its relevance in various pathological conditions. Mutations in the TMC4 gene have been linked to hearing loss, making it a crucial target for understanding the molecular mechanisms of auditory function and dysfunction. The study of recombinant TMC4 protein allows researchers to investigate its biophysical properties, functional roles, and interactions with other proteins in vitro. Advances in structural biology techniques, such as cryo-electron microscopy and X-ray crystallography, have further propelled this research by providing insights into the protein's architecture and ion-conducting pathways. Given the importance of TMC4 in hearing, understanding its function at the molecular level could lead to novel therapeutic strategies for treating auditory disorders. Overall, TMC4 recombinant protein research represents a significant frontier in the fields of molecular biology, genetics, and medical research, with far-reaching implications for both basic science and clinical applications.
