关键信息
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基因名
GRM5
- 应用
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别名
mGluR5 (GPRC1E) (MGLUR5)
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P41594
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表达区间
22-580aa
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分子量
70.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The metabotropic glutamate receptor 5 (GRM5) is a G protein-coupled receptor that plays a pivotal role in synaptic transmission and plasticity, making it a significant target for studying neurological disorders. Dysregulation of GRM5 has been implicated in various conditions, including epilepsy, anxiety, and schizophrenia. Due to its involvement in excitatory neurotransmission, understanding GRM5's functional mechanisms can provide insights into these disorders and potentially yield novel therapeutic strategies. The production of recombinant GRM5 proteins is essential for structural and functional studies, allowing researchers to explore its binding properties, signaling pathways, and interactions with ligands or other cellular components. The reconstitution of GRM5 in a controlled environment facilitates high-throughput screening of modulators and therapeutic agents, advancing our knowledge of its role in neurological processes. Furthermore, using recombinant proteins can aid in the elucidation of GRM5's activation mechanisms and its subsequent downstream effects, which may unlock new avenues for drug development. Overall, GRM5 recombinant protein research is critical in bridging the gap between basic neuroscience and clinical application, paving the way for innovative interventions in treating neurological diseases linked to this receptor.
